426205

β-Lactamase, Bacillus cereus 569/H9

• 別名: β-Lactamase, Bacillus cereus 569/H9, Penicillinase
• CAS番号: 9073-60-3
• Enzyme Commission number: 3.5.2.6 (BRENDA, IUBMB)
• MDL番号: MFCD00131819
• UNSPSCコード: 12352202
• NACRES: NA.54

特性

• 由来生物: Bacillus sp. (Bacillus cereus)
• 品質水準: 100
• フォーム: lyophilized
• 包装: vial of ≥50 units β-lactamase II; vial of ≥500 units β-lactamase I
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 溶解性: sterile distilled water: soluble
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

β-Lactamase produced by bacteria shares sequence homology to penicillin-binding proteins. This enzyme is found in Gram-negative bacteria. β-Lactamases have four molecular classes, named A, B, C, and D. A, C, and D form an acyl-enzyme via active site serine residue. Class B β-lactamases are metalloenzymes, which have a zinc ion at their active site for β-lactam hydrolysis.

生物化学的／生理学的作用

β-Lactamase hydrolyzes β-lactum antibiotics and is the chief cause of resistance to β-lactam antibiotics development by bacteria. Mutations in the β-lactamases are associated with extended-spectrum β-lactamases (ESBLs).

警告

Toxicity: Harmful (C)

単位の定義

One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol benzyl penicillin and 1.0 µmol of cephalosporin C, respectively, per min at 25°C.

再構成

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Danger
• 危険有害性情報: H317,H334
• 注意書き: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• 危険有害性の分類: Resp. Sens. 1 - Skin Sens. 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable