410960

Ischemin

A cell-permeable azobenzene compound that reversibly targets CBP-BRD acetyl-lysine binding pocket with moderate selectivity over BAZ1B, PCAF, BRD4-1 and BAZ2B.

• 別名: Ischemin, (E)-5-(2-Amino-4-hydroxy-5-methyl-phenylazo)-2,4-dimethyl-benzenesulfonic acid, MS120, BRD4 Inhibitor II
• 実験式（ヒル表記法）: C₁₅H₁₇N₃O₄S
• CAS番号: 1357059-00-7
• 分子量: 335.38
• MDL番号: MFCD28044303
• UNSPSCコード: 12352200
• NACRES: NA.51

特性

• 品質水準: 100
• アッセイ: ≥99% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: orange-red
• 溶解性: DMSO: 50 mg/mL, orange
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: CC1=C(/N=N/C2=C(N)C=C(O)C(C)=C2)C=C(C(C)=C1)S(=O)(O)=O

詳細

詳細

A cell-permeable azobenzene compound that reversibly targets CREB-binding protein bromodomain (CBP-BRD) acetyl-lysine binding pocket (K_d = 19 µM) with moderate selectivity over BAZ1B, PCAF, BRD4-1 and BAZ2B (K_d = 37, 41, 70 and >100 µM, respectively) and disrupts CBP interaction with the binding partners. Blocks CBP-p53 interaction and alters the post-translational modification states on p53 and histones. Shown to inhibit the transcription functions of p53 on DNA damage (IC₅₀ = 5 µM for p53-induced p21 activation in Luc-U2OS cells) and suppress cardiac myocyte apoptosis during ischemia conditions.

包装

Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

その他情報

Borah, J.C., et al. 2011, Chem. Biol.18, 531.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable