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詳細
Research area: Immunology and Cytokines
Human sequence IL-6 is active in murine cells.1 µg is equivalent to 7.0 x 103 WHO units. 8-20 pg/ml as measured in a cell proliferation assay with a factor-dependent murine plasmacytoma cell line, B9.
Human sequence IL-6 is active in murine cells.1 µg is equivalent to 7.0 x 103 WHO units. 8-20 pg/ml as measured in a cell proliferation assay with a factor-dependent murine plasmacytoma cell line, B9.
アプリケーション
Interleukin-6has been used:
- to study IL-6 effects on lung cancer-derived mesenchymal stromalcells (MSCs) and to test the ability of statins to block these effects.
- toinvestigate the role of IL-6 in the development of coronary artery spasm (CAS).
- to study the effects of IL-6 on the bioactivity of therapeutic interferon (IFN)variants.
生物化学的／生理学的作用
Interleukin-6 (IL-6) is a prototypic pleiotropic, pro-inflammatory cytokine that is expressed in response to injury, inflammation, and infection.(5) IL-6 triggers the activation of three distinct pathways: signal transducer and activator of transcription 3 (STAT-3), extracellular signal-regulated kinase 1 and 2 (Erk1/2), and protein kinase b/protein kinase b-alpha (Akt). Consequently, this activation leads to the upregulation of numerous genes that impact essential cellular processes including survival, proliferation, differentiation, osteogenesis/osteolysis, angiogenesis, and immune modulation. It stimulates the production of acute-phase proteins by hepatocytes. IL-6 is also known to induce skeletal muscle protein breakdown. Induces growth and differentiation of B cells, T cells, and hepatocytes. Stimulates growth and inhibits constitutive, protein synthesis-independent apoptosis of murine B cell hybridoma 7TD1. IL-6 is also considered as a potential marker of adipocyte differentiation. Interleukin-6 is a protein produced by a variety of cell types including T-lymphocytes, monocytes, diploid fibroblasts, hepatocytes, cardiac myxomas, certain cervical cancer cells, bladder cell carcinomas, vascular endothelial cells, and human myelomas. It has a variety of biological effects and does not show a high degree of species specificity.
警告
Toxicity: Standard Handling (A)
物理的形状
Carrier free.
再構成
Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
Reconstitute to 0.1-1.0 mg/ml in 100 mM acetic acid.
その他情報
Vicennati, V., et al. 2002. Int. J. Obes. Relat. Metab. Disord.26, 9.
Vallieres, L., and Rivest, S. 1999. Endocrinology140, 3890.
Goodman, M.N. 1994. Proc. Soc. Exp. Biol. Med. 205, 182.
Liu, J., et al. 1994. Cell Immunol.155, 229.
Van Snick, J. 1990. Annu. Rev. Immunol.8, 253.
Vallieres, L., and Rivest, S. 1999. Endocrinology140, 3890.
Goodman, M.N. 1994. Proc. Soc. Exp. Biol. Med. 205, 182.
Liu, J., et al. 1994. Cell Immunol.155, 229.
Van Snick, J. 1990. Annu. Rev. Immunol.8, 253.
法的情報
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類コード
11 - Combustible Solids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
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Jan Code
407652-10UG:
407652-UG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Yen-Kuang Lin et al.
Oxidative medicine and cellular longevity, 2022, 9964689-9964689 (2022-02-01)
Apolipoprotein (a)/lipoprotein(a) (Lp(a)), a major carrier of oxidized phospholipids, and α7-nicotinic acetylcholine receptor (α7-nAChR) may play an important role in the development of coronary artery spasm (CAS). In CAS, the association between Lp(a) and the α7-nAChR-modulated inflammatory macrophage polarization and
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