361548

GSK-3β Inhibitor VII

The GSK-3β Inhibitor VII, also referenced under CAS 99-73-0, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 別名: GSK-3β Inhibitor VII, α-4-Dibromoacetophenone, TPK I Inhibitor, Tau Protein Kinase I Inhibitor
• 実験式（ヒル表記法）: C₈H₆Br₂O
• CAS番号: 99-73-0
• 分子量: 277.94
• MDL番号: MFCD00000200
• UNSPSCコード: 12352100
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated; protect from light
• 色: white
• 溶解性: DMSO: 5 mg/mL
• 輸送温度: wet ice
• 保管温度: −20°C
• SMILES記法: BrCC(=O)c1ccc(cc1)Br
• InChI: 1S/C8H6Br2O/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2
• InChI Key: FKJSFKCZZIXQIP-UHFFFAOYSA-N

詳細

詳細

A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC₅₀ = 0.5 µM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 µM.

A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, selective, and non-ATP competitive inhibitor of GSK-3β (IC₅₀ = 500 nM). Does not affect the activity of PKA even at concentrations as high as 100 µM.

生物化学的／生理学的作用

Cell permeable: yes

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 0.5 µM against GSK-3β

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

その他情報

Conde, S., et al. 2003. J. Med. Chem.46, 4631.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS05
• シグナルワード: Danger
• 危険有害性情報: H314
• 注意書き: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• 危険有害性の分類: Skin Corr. 1B
• 保管分類コード: 8A - Combustible corrosive hazardous materials
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable