341608

FGF Receptor Tyrosine Kinase Inhibitor

The FGF Receptor Tyrosine Kinase Inhibitor, also referenced under CAS 192705-79-6, controls the biological activity of FGF Receptor Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 別名: FGF Receptor Tyrosine Kinase Inhibitor, 1-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea, PD 166866, PD 166866, 1-(2-Amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea
• 実験式（ヒル表記法）: C₂₀H₂₄N₆O₃
• CAS番号: 192705-79-6
• 分子量: 396.44
• MDL番号: MFCD12922514
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: off-white
• 溶解性: DMSO: 10 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
• InChI Key: NHJSWORVNIOXIT-UHFFFAOYSA-N

詳細

詳細

A cell-permeable pyridopyrimidinyl urea compound that acts a potent, ATP-competitive inhibitor of FGFR (IC₅₀ = 60 nM using FGFR1) with excellent selectivity over PDGFRβ, EGFR, insulin receptor, and c-Src (IC₅₀ >50 µM).

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Panek, R.L., et al. 1998. J. Pharm. Exp. Ther.286, 569.
Hamby, J.M., et al. 1997. J. Med. Chem.40, 2296.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable