230950

Ciglitazone

A potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective PPARγ agonist (EC₅₀ = 3 µM).

• 別名: Ciglitazone, (±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione, PPAR Agonist II, PPARγ Agonist I
• 実験式（ヒル表記法）: C₁₈H₂₃NO₃S
• CAS番号: 74772-77-3
• 分子量: 333.45
• MDL番号: MFCD00865499
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: tan
• 溶解性: DMSO: ≥25 mg/mL; ethanol: ≥25 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C18H23NO3S/c1-18(9-3-2-4-10-18)12-22-14-7-5-13(6-8-14)11-15-16(20)19-17(21)23-15/h5-8,15H,2-4,9-12H2,1H3,(H,19,20,21)
• InChI Key: YZFWTZACSRHJQD-UHFFFAOYSA-N

詳細

詳細

A potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective PPARγ agonist (EC₅₀ = 3 µM).

A potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC₅₀ = 3 µM).

生物化学的／生理学的作用

Cell permeable: no

EC50 = 3 µM as PPARγ agonist

Primary Target
Selective PPARγ agonist

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Harmful (C)

再構成

Stock solutions are stable for up to 3 months at -20°C.

その他情報

Jha, R.J. 1999. Clin. Exp. Hypertens. 21, 157.
Xin, X., et al. 1999. J. Biol. Chem. 274, 9116.
Lohrke, B., et al. 1998. J. Endocrinol. 159, 429.
Willson, T.M., et al. 1996. J. Med. Chem. 39, 665.
Cantello, B.C., et al. 1994. J. Med. Chem. 37, 3977.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable