516566

PPARγ Antagonist III, G3335

The PPARγ Antagonist III, G3335, also referenced under CAS 36099-95-3, controls the biological activity of PPARγ.

• 別名: PPARγ Antagonist III, G3335, H-Trp-Glu-OH
• 実験式（ヒル表記法）: C₁₆H₁₉N₃O₅
• CAS番号: 36099-95-3
• 分子量: 333.34
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (TLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: water: 30 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C16H19N3O5/c17-11(7-9-8-18-12-4-2-1-3-10(9)12)15(22)19-13(16(23)24)5-6-14(20)21/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/m0/s1
• InChI Key: PWIQCLSQVQBOQV-AAEUAGOBSA-N

詳細

詳細

A cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist (K_D = ~ 8 µM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC₅₀ = 31.9 µM) in transfected COS-7 cells.

A cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist (K_D ~8 µM). Shown to inhibit the agonist activity of Rosiglitazone (100 nM) in a dose-dependent manner (IC₅₀ = 31.9 µM) in transfected COS-7 cells.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
PPARγ

Product does not compete with ATP.

Reversible: yes

kd = ~ 8 µM as PPARγ antagonist

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

調製ノート

Addition of a small amount of acid or base may be required for complete solubilization.

再構成

Following reconstitution aliquot freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

その他情報

Ye, F., et al. 2006. Chembiochem7, 74.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable