176870
Angiotensinogen, Human Plasma
Native angiotensinogen from human plasma that is cleaved by renin to generate angiotensin I. It is a part of the renin-angiotensin system that regulates blood pressure and fluid balance.
別名:
Angiotensinogen, Human Plasma, AGT, Hypertensinogen, Serpin A8
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About This Item
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品質水準
アッセイ
≥95% (SDS-PAGE)
形状
solid
メーカー/製品名
Calbiochem®
保管条件
OK to freeze
テクニック
cell based assay: suitable
溶解性
water: soluble
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
ambient
保管温度
−20°C
遺伝子情報
human ... AGT(183)
詳細
Research area: CELL SIGNALING
Native angiotensinogen from human plasma is an α2-globulin present in plasma at about 7 mg/100 ml.
Angiotensinogen serves as a precursor for the production of angiotensin. In humans, angiotensinogen is composed of 485 amino acids. It is primarily synthesized and continuously secreted by the liver.
Native angiotensinogen from human plasma is an α2-globulin present in plasma at about 7 mg/100 ml.
Angiotensinogen serves as a precursor for the production of angiotensin. In humans, angiotensinogen is composed of 485 amino acids. It is primarily synthesized and continuously secreted by the liver.
アプリケーション
Angiotensinogen has been used for the detection and analysis of the complexes formed between angiotensinogen and proform of eosinophil major basic protein (ProMBP) in both serum and amniotic fluid during pregnancy through ELISA.
生物化学的/生理学的作用
Angiotensinogen acts as a precursor molecule in the renin-angiotensin-aldosterone system (RAAS) pathway. It is a part of the renin-angiotensin system that regulates blood pressure and fluid balance. Moreover, overactivation of the RAAS system has been associated with the development of several types of cancer, cardiovascular and renal diseases. Furthermore, in certain cancers angiotensin II has been shown to promote cancer metastasis.
警告
Toxicity: Standard Handling (A)
物理的形状
Lyophilized from 50 mM sodium phosphate, 150 mM NaCl, pH 7.0.
調製ノート
Please refer to vial label for lot-specific concentration prior to lyophilization.
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
再構成
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
その他情報
Jeunemaitre, X., et al. 1992. Cell71, 169.
Tewksbury, D.A. 1983. Fed. Proc.42, 2724.
Tewksbury, D.A. 1983. Fed. Proc.42, 2724.
法的情報
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
176870-1MG:
176870-UG:
176870-100UG:
176870-0MG:
試験成績書(COA)
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