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Merck
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主要文書

安全性情報

171261

Sigma-Aldrich

Dorsomorphin

≥95% (HPLC), liquid, AMPK inhibitor, Calbiochem

別名:

InSolution AMPK Inhibitor, Compound C, Dorsomorphin, AMPK Inhibitor I, BMP Inhibitor I

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About This Item

実験式（ヒル表記法）:
C24H25N5O
CAS番号:
866405-64-3
分子量:
399.49
MDL番号:
MFCD08705402
UNSPSCコード:
12352200
NACRES:
NA.77

product name

AMPK Inhibitor, Compound C, InSolution, ≥95%, 10 mM, AMPK Inhibitor

品質水準

100

アッセイ

≥95% (HPLC)

形状

liquid

メーカー／製品名

Calbiochem®

保管条件

OK to freeze
desiccated (hygroscopic)
protect from light

輸送温度

wet ice

保管温度

2-8°C

InChI

1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2

InChI Key

XHBVYDAKJHETMP-UHFFFAOYSA-N

詳細

A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo.

生物化学的／生理学的作用

Cell permeable: yes
EC100 = 2.5 µM against BMP pathway-dependent dorsoventral development; EC50 = 5 µM against VEGF signaling-dependent intersomitic vessel formation in zebrafish embryo in vivo
Primary Target
AMPK
Product competes with ATP.
Reversible: yes
Target IC50: 25.1, 148, and 234.6 nM, against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity, respectively

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

物理的形状

Supplied as a 10 mM (1 mg/250 µl) solution of AMPK Inhibitor, Compound C (Cat. No. 171260) in DMSO.

再構成

Following initial use, aliquot and freeze (-20°C). Once opened, stock solutions are stable for up to 3 months at -20°C.

その他情報

Hao, J., et al. 2010. ACS Chem.Biol.5, 245.
Kim, E.K., et al. 2004. J. Biol. Chem.279, 19970.
Lee, M., et al. 2003. J. Biol. Chem.278, 39653.
Inoki, K., et al. 2003. Cell115, 577.
Fryer, L.G., 2002. FEBS Lett.531, 189.
Zhou, G., et al. 2001. J. Clin. Invest.108, 1167.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

保管分類コード

10 - Combustible liquids

WGK

WGK 2

引火点(°F)

188.6 °F - closed cup - (Dimethylsulfoxide)

引火点(℃)

87 °C - closed cup - (Dimethylsulfoxide)

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

消防法

第4類:引火性液体
第三石油類
危険等級III
非水溶性液体

Jan Code

171261-1MG:

試験成績書（COA）

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Sigma-Aldrich

D8946

DMH1

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Sigma-Aldrich

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AICA-Riboside

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Sigma-Aldrich

662009

U0126

SBI-0206965 ≥98% (HPLC)

Sigma-Aldrich

SML1540

SBI-0206965

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Sigma-Aldrich

524572

Phosphatase, Alkaline, Calf Intestine

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Sigma-Aldrich

124005

Akt Inhibitor

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Sigma-Aldrich

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Sigma-Aldrich

71945

サリチル酸ナトリウム

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Sigma-Aldrich

553210

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Sigma-Aldrich

S8307

SB 203580

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