14-787-M

PI3 Kinase (p110α (H1047R)/p85α) Murine, 10 µg

Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation H1047R α & untagged, recombinant, full length mouse p85α. For use in Kinase Assays.

• UNSPSCコード: 12352200
• eCl@ss: 32160405
• NACRES: NA.32

特性

• 由来生物: mouse
• 品質水準: 100; 300
• リコンビナント: expressed in baculovirus infected Sf21 cells
• 分子量: M_w 129 kDa (p110α; H1047R); M_w 83.6 kDa (p85α)
• メーカー／製品名: Upstate^®
• テクニック: activity assay: suitable (kinase)
• NCBIアクセッション番号: NM_006218.2
• UniProtアクセッション番号: P42336
• 遺伝子情報: mouse ... PIK3CA(18706)

詳細

詳細

Complex of N-terminal 6His-tagged, recombinant, full-length mouse p110α containing the mutation H1047R αand untagged, recombinant, full length mouse p85α.

Product Source: Coexpressed by baculovirus in Sf21 insect cells.

The H1047R substitution in p110α is associated with a number of human cancers. The residue is conserved between the human and mouse sequences. In vitro studies have shown that this mutation confers increased lipid kinase activity compared to wild type, and is able to induce oncogenic transformation.

アプリケーション

Research Category
炎症及び免疫

生物化学的／生理学的作用

Protein Target: PI3Kα/p85α

Target Sub-Family: PI3K/PI4K

包装

Also available in 250μg size --call for pricing and availability and reference catalog number 14-787M when ordering the 250μg size.

物理的形状

Ni²⁺/NTA-agarose

保管および安定性

Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.

その他情報

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法的情報

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H317
• 注意書き: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危険有害性の分類: Skin Sens. 1
• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable