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Merck

126658

Sigma-Aldrich

Albumin, Human Serum, Fraction V, High Purity

別名:

Albumin, Human Serum, Fraction V, High Purity

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About This Item

CAS番号:
MDL番号:
UNSPSCコード:
12352202
NACRES:
NA.25

アッセイ

≥95% (cellulose acetate electrophoresis)

形状

solid

メーカー/製品名

Calbiochem®

保管条件

OK to freeze

pI 

4.7

溶解性

aqueous buffer: 5 mg/mL
water: 5 mg/mL

輸送温度

ambient

保管温度

−20°C

InChI

1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11

InChI Key

QYSGYZVSCZSLHT-UHFFFAOYSA-N

詳細

Human serum albumin (HSA) is an unglycosylated, soluble, and globular monomeric protein. It is abundantly found in the plasma, with a multidomain comprising three homologous domains, called I, II, and III. Three of these domains have subdomains A and B with common structural motifs. The HSA gene is localized on the human chromosome 4q13.3.

アプリケーション

Albumin, human serum, fraction V, high purity has been used to determine the binding affinity of nanobody α human serum albumin (HSA) to HSA and injected to detect the signals of tandem binding of human interleukin (IL-21R), IL-21-αHSA, and HSA. It has also been used to study the effects of fetuin-A phosphorylation on calciprotein particles (CPP) uptake.

生物化学的/生理学的作用

Human serum albumin (HSA) plays a major role as a carrier protein for fatty acids, thyroid hormones, and steroids. It is involved in stabilizing extracellular fluid volume. HSA is used to treat hemodialysis, acute liver failure, chronic liver disease. It serves as an excipient for vaccines and therapeutic protein drugs. HSA is implicated in biological applications, including ligand trapping, nano delivery of drugs, and fusion proteins.

警告

Toxicity: Standard Handling (A)

調製ノート

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

再構成

Alternatively, this product may be stored in the refrigerator (4°C) prior to reconstitution. Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

126658-50GM:
126658-1GM:
126658-GM:
126658-5GM:


試験成績書(COA)

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L S Schlesinger et al.
The Journal of experimental medicine, 174(5), 1031-1038 (1991-11-01)
Previous studies from this laboratory have demonstrated that Mycobacterium leprae, an obligate intracellular bacterial parasite, enters human mononuclear phagocytes via complement receptors on these host cells and bacterium-bound C3. The present study investigates the role of M. leprae surface molecules
Tanaya Chatterjee et al.
PloS one, 7(5), e37468-e37468 (2012-06-01)
Virstatin is a small molecule that inhibits Vibrio cholerae virulence regulation, the causative agent for cholera. Here we report the interaction of virstatin with human serum albumin (HSA) using various biophysical methods. The drug binding was monitored using different isomeric
B Grunfeld et al.
Hypertension (Dallas, Tex. : 1979), 15(3), 257-261 (1990-03-01)
Renal functional reserve, microalbuminuria, and plasma atrial natriuretic factor were measured in 21 offspring (9.5 +/- 0.5 years of age, mean +/- SEM) of hypertensive parents and in eight children (10 +/- 0.5 years of age) with no family history
Edward R Smith et al.
PloS one, 8(4), e60904-e60904 (2013-04-12)
The formation of fetuin-A-containing calciprotein particles (CPP) may facilitate the clearance of calcium phosphate nanocrystals from the extracellular fluid. These crystals may otherwise seed extra-osseous mineralization. Fetuin-A is a partially phosphorylated glycoprotein that plays a critical role in stabilizing these
Rene C Chan et al.
Methods in molecular biology (Clifton, N.J.), 322, 289-300 (2006-06-03)
Nuclear import is a critical process for the cell: molecules are selectively permitted into the nuclear interior where the sheltered genome resides. The process of nuclear import can be biochemically studied in vitro using nuclei reconstituted from Xenopus egg extract

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