P-019

フェノバルビタール-D₅ (員環) 溶液

(deuterium label on ring), 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• 実験式（ヒル表記法）: C₁₂D₅H₇N₂O₃
• CAS番号: 72793-46-5
• 分子量: 237.27
• UNSPSCコード: 41116107
• NACRES: NA.24

特性

• グレード: certified reference material
• 形状: liquid
• 特徴: Snap-N-Spike^®/Snap-N-Shoot^®
• 包装: ampule of 1 mL
• メーカー／製品名: Cerilliant^®
• drug control: Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• 濃度: 1.0 mg/mL in methanol
• テクニック: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• アプリケーション: forensics and toxicology
• フォーマット: single component solution
• 保管温度: −20°C
• SMILES記法: [2H]c1c([2H])c([2H])c(c([2H])c1[2H])C2(CC)C(=O)NC(=O)NC2=O
• InChI: 1S/C12H12N2O3/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16/h3-7H,2H2,1H3,(H2,13,14,15,16,17)/i3D,4D,5D,6D,7D
• InChI Key: DDBREPKUVSBGFI-DKFMXDSJSA-N

詳細

詳細

臨床毒性学、尿薬物テスト、または法医学分析のためのGC/MSまたはLC/MSでの使用において、フェノバルビタールレベルの定量に好適な内部標準。フェノバルビタールは、欠神発作を除くてんかん発作の全タイプを治療するのに使用されるバルビツール酸系化合物です。フェノバルビタールは、最も古く、最も幅広く用いられている抗痙攣薬です。

アプリケーション

• Rapid quantification of phenobarbital and barbital in human whole blood by liquid-liquid extraction combined with DART-orbitrap-HRMS: This study presents a method using Phenobarbital-D5 as an internal standard for the rapid quantification of barbiturates in blood samples, crucial for forensic toxicology and drug metabolism studies. The approach enhances the precision of mass spectrometry analyses, making it essential for researchers employing high-resolution mass spectrometry in pharmacokinetic analyses (Ke et al., 2023).


• Internal standard application strategies in mass spectrometry imaging by desorption electrospray ionization mass spectrometry: This research outlines strategic uses of Phenobarbital-D5 as an internal standard in mass spectrometry imaging, particularly desorption electrospray ionization mass spectrometry (DESI-MS). It underscores the compound′s utility in enhancing the accuracy of spatially-resolved mass spectrometry, pivotal for biochemical and pharmacological research (Perez, Ifa, 2021).


• Determination of barbiturates in hair samples by using a validated UHPLC-HRMS method: application in investigation of drug-facilitated sexual assault: This publication highlights the application of Phenobarbital-D5 in ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry (UHPLC-HRMS) for analyzing barbiturates in hair samples. The method provides crucial insights into drug metabolism and facilitates the investigation of drug-facilitated crimes, serving as a reliable analytical reference standard in forensic science (Wen et al., 2022).

法的情報

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS02,GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H225,H301 + H311 + H331,H370
• 注意書き: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• 危険有害性の分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• ターゲットの組織: Eyes,Central nervous system
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 2
• 引火点(°F): 49.5 °F - closed cup
• 引火点(℃): 9.7 °C - closed cup