N-903

ノルダゼパム-d₅ 溶液

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• 実験式（ヒル表記法）: C₁₅D₅H₆ClN₂O
• CAS番号: 65891-80-7
• 分子量: 275.74
• EC Number: 200-659-6
• UNSPSCコード: 41116107
• NACRES: NA.24

特性

• グレード: certified reference material
• 形状: liquid
• 特徴: Snap-N-Spike^®/Snap-N-Shoot^®
• 包装: ampule of 1 mL
• メーカー／製品名: Cerilliant^®
• drug control: Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• 濃度: 100 μg/mL in methanol
• テクニック: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• アプリケーション: clinical testing
• フォーマット: single component solution
• 保管温度: −20°C
• SMILES記法: [2H]c1c([2H])c([2H])c(c([2H])c1[2H])C2=NCC(=O)Nc3ccc(Cl)cc23
• InChI: 1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)/i1D,2D,3D,4D,5D
• InChI Key: AKPLHCDWDRPJGD-RALIUCGRSA-N

詳細

詳細

ノルジアゼパムは、不安やパニック発作の治療のために処方されるベンゾジアゼピンです。この安定標識された内部標準は、尿薬物検査、臨床毒性学、法医学分析、または同位体希釈法のためのLC/MSもしくはGC/MSによる尿、血清、血漿中のノルジアゼパムレベルの定量に適しています。ノルジアゼパムは、ベンゾジアゼピンジアゼパムとクロロジアゼポキシドの主要代謝生成物でもあります。

アプリケーション

• Validation in psychoactive drug detection: A study developed a rapid UPLC-MS/MS method to detect multiple psychoactive substances, including Nordiazepam-d5, in post-mortem whole blood samples, highlighting its utility in forensic toxicology and drug monitoring (Barone et al., 2023).
• Application in neonatal drug exposure studies: Research employed liquid chromatography-high-resolution mass spectrometry, utilizing Nordiazepam-d5 as a reference, to determine venlafaxine exposure during gestation through neonatal hair analysis, illustrating its value in pediatric forensic investigations (Favretto et al., 2010).
• Detection in hair samples: The use of Nordiazepam-d5 was explored in a French study for the identification of benzodiazepine consumption in hair samples from drug addicts, demonstrating its effectiveness as a stable isotope-labeled standard for chronic exposure analysis (Vayssette et al., 1996).
• GC/MS analysis for benzodiazepine metabolites: A method was developed to analyze common benzodiazepine metabolites, including Nordiazepam, in urine, showcasing the application of Nordiazepam-d5 in creating more reliable and reproducible results in toxicological testing (West and Ritz, 1993).

法的情報

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS02,GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H225,H301 + H311 + H331,H370
• 注意書き: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• 危険有害性の分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• ターゲットの組織: Eyes,Central nervous system
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 2
• 引火点(°F): 49.5 °F - closed cup
• 引火点(℃): 9.7 °C - closed cup