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Merck
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安全性情報

H-004

Supelco

Hydromorphone solution

1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

実験式（ヒル表記法）:
C17H19NO3
CAS番号:
466-99-9
分子量:
285.34
EC Number:
200-659-6
MDL番号:
MFCD00864214
UNSPSCコード:
41116107
PubChem Substance ID:
329815100
NACRES:
NA.24

グレード

certified reference material

品質水準

300

フォーム

liquid

包装

ampule of 1 mL

メーカー／製品名

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

濃度

1 mg/mL in methanol

テクニック

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

アプリケーション

forensics and toxicology

フォーマット

single component solution

保管温度

−20°C

SMILES記法

CN1CC[C@@]23[C@H]4CCC(=O)[C@@H]2Oc5c(O)ccc(C[C@@H]14)c35

InChI

1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,16,19H,3,5-8H2,1H3/t10-,11+,16-,17-/m0/s1

InChI Key

WVLOADHCBXTIJK-YNHQPCIGSA-N

遺伝子情報

human ... OPRM1(4988)

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詳細

A certified reference standard suitable for use as a starting material in calibrators or controls for a variety of LC/MS or GC/MS applications from forensic analysis, clinical toxicology, and pain prescription monitoring to urine drug testing and pharmaceutical research. Hydromorphone, marketed under brand names including Palladone and Dilaudid®, is a very potent opioid analgesic. The drug is often used medicinally as an alternative to morphine for treatment of pain or as a cough suppressant for painful coughing resulting from continued bronchial irritation.

アプリケーション


  • Quantitative analysis of Haloperidol: Development of a sensitive LC-MS/MS method for Haloperidol quantification in human plasma, employing Haloperidol-D₄ as an internal standard and incorporating phospholipid removal pretreatment to enhance detection accuracy (Zidekova et al., 2021).

  • Automated determination in toxicological studies: Utilization of Haloperidol-D₄ in an automated method for toxicokinetic studies of Trimebutine and its metabolites, demonstrating the compound′s role in high-throughput forensic toxicology (Larabi et al., 2015).

  • High-throughput drug monitoring: Application of ′high throughput′ solid-phase extraction and turbo ionspray LC-MS-MS for Haloperidol determination in plasma, showcasing the efficiency of Haloperidol-D₄ as a stable isotope-labeled standard for enhancing bioanalytical procedures (Hempenius et al., 1999).



法的情報

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Dilaudid is a registered trademark of Purdue Pharma L.P.

関連製品

製品番号
詳細
価格

H-010

Hydromorphone-D3 solution, 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-006

Hydromorphone-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

P-071

Pain Management Multi-component Opiate Mixture-13 solution, 100 μg/mL each component (10 μg/mL Fentanyl), ampule of 1.0 mL, certified reference material, Cerilliant®

H-049

Hydromorphone-D6 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-050

Hydromorphone-D6 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

H-051

Hydromorphone-3-β-D-glucuronide, 100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

N-107

Norhydromorphone hydrochloride solution, 1.0 mg/mL in methanol (as free base), certified reference material, ampule of 1 mL, Cerilliant®

H-004S

Hydromorphone solution, 1 mg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant®

ピクトグラム

FlameSkull and crossbonesHealth hazard
GHS02,GHS06,GHS08

シグナルワード

Danger

危険有害性情報

H225,H301 + H311 + H331,H370

危険有害性の分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

ターゲットの組織

Eyes

保管分類コード

3 - Flammable liquids

WGK

WGK 1

引火点(°F)

49.5 °F - closed cup

引火点(℃)

9.7 °C - closed cup

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

H-004-1ML:
H-004-CC:

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試験成績書（COA）

Lot/Batch Number

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以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

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Bonnie L Hay Kraus
Veterinary anaesthesia and analgesia, 40(1), 28-34 (2012-10-23)
The goal of this study was to evaluate the effectiveness of maropitant (Cerenia(®)) in preventing vomiting after premedication with hydromorphone. Randomized, blinded, prospective clinical study. Eighteen dogs ASA I/II admitted for elective orthopedic surgical procedures. The dogs were a mixed
Martin E Hale et al.
Journal of opioid management, 8(5), 299-314 (2012-12-19)
This analysis was designed to assess the pooled safety and tolerability of once-daily hydromorphone extended release (ER) (OROS® hydromorphone ER) in opioid-naïve and opioid-tolerant patients with chronic cancer or noncancer pain. Safety results were pooled from 13 controlled and uncontrolled
Jessica R Barker et al.
Veterinary surgery : VS, 42(1), 79-84 (2012-12-12)
To evaluate efficacy of a topical epidural analgesia used alone, or in combination with hydromorphone, against a standard pain protocol for the 48 hours immediately after hemilaminectomy. Randomized, blinded, controlled, clinical trial. Dogs (n = 30) with thoracolumbar intervertebral disc disease
Leah C Stern et al.
Journal of the American Veterinary Medical Association, 241(3), 344-347 (2012-07-21)
To determine the frequency of postoperative vomiting in dogs undergoing routine orthopedic surgery that were treated with hydromorphone and whether that frequency would vary on the basis of administration route. Noncontrolled clinical trial. Animals-58 client-owned dogs with cranial cruciate ligament
Erik Rauch
AANA journal, 80(4 Suppl), S25-S32 (2012-12-20)
Despite compelling evidence for the safety and efficacy of intrathecal hydromorphone, the use of this opioid intrathecally for the pain management of patients undergoing cesarean delivery has not been widely accepted. The purpose of this retrospective study was to compare
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資料

Benefits of Ascentis Express Phenyl-Hexyl over Biphenyl for the Separation of Pain Management Opiates

Although both biphenyl and phenyl-hexyl phases can resolve these compounds, the former exhibits excellent peak shape and substantially less silanol-derived ion exchange activity.

プロトコル

LC/MS (TOF) Analysis of Drugs and Their Glucuronide Metabolites in Urine on Titan™ C18 after Solid Phase Extraction (SPE) using Supel™-Select SCX, β-Glucuronidase Enzyme Digestion

-THC solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material

Using UHPLC/MS (TOF) for Detection of Drugs and Metabolites in Urine Following Optimized Enzymatic Hydrolysis Conditions

To optimize hydrolysis using β-glucuronidase, factors such as incubation time, temperature, hydrolysis pH, enzyme source, and enzyme concentration must be evaluated for each glucuronide metabolite to be analyzed.

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