C003

(R)-(-)-3-キヌクリジニル ベンジラート

• 別名: (R)-(-)-QNB, (R)-(-)-キヌクリジニル-α-ヒドロキシジフェニルアセタート
• 実験式（ヒル表記法）: C₂₁H₂₃NO₃
• CAS番号: 62869-69-6
• 分子量: 337.41
• MDL番号: MFCD00085375
• UNSPSCコード: 12352005
• PubChem Substance ID: 57653972
• NACRES: NA.22

特性

• フォーム: solid
• 品質水準: 100
• 保管温度: 2-8°C
• SMILES記法: OC(C(=O)O[C@H]1CN2CCC1CC2)(c3ccccc3)c4ccccc4
• InChI: 1S/C21H23NO3/c23-20(25-19-15-22-13-11-16(19)12-14-22)21(24,17-7-3-1-4-8-17)18-9-5-2-6-10-18/h1-10,16,19,24H,11-15H2/t19-/m0/s1
• InChI Key: HGMITUYOCPPQLE-IBGZPJMESA-N
• 遺伝子情報: rat ... Chrm1(25229) , Chrm2(81645) , Chrm3(24260)

詳細

アプリケーション

(R)-(-)-3-Quinuclidinyl benzilate can be used as a reactant for the synthesis of quaternary ammonium derivatives of (3R)-quinuclidinol esters as potential muscarinic M3 antagonists. It can also be employed in the preparation of potent muscarinic cholinergic antagonist (R)-[N-methyl-3H]quinuclidinyl benzilate methiodide by alkylation with methyl iodide.

• Pharmacological agent used as muscarinic M3 antagonist for the inhaled treatment of chronic obstructive pulmonary disease (COPD)

生物化学的／生理学的作用

Nonselective muscarinic acetylcholine receptor antagonist. More potent enantiomer of QNB.

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301 + H311 + H331
• 注意書き: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• 危険有害性の分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges