934240

Pomalidomide acetic acid

≥95.0%

• 別名: N-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]glycine
• 実験式（ヒル表記法）: C₁₅H₁₃N₃O₆
• CAS番号: 927670-97-1
• 分子量: 331.28
• MDL番号: MFCD31667076
• UNSPSCコード: 12352106
• NACRES: NA.21

特性

• ligand: pomalidomide
• 品質水準: 100
• アッセイ: ≥95.0%
• フォーム: powder or crystals
• 保管温度: 2-8°C

詳細

アプリケーション

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

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その他情報

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法的情報

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• ピクトグラム: GHS08
• シグナルワード: Warning
• 危険有害性情報: H361d,H373
• 注意書き: P202 - P260 - P280 - P308 + P313 - P405 - P501
• 危険有害性の分類: Repr. 2 - STOT RE 2
• ターゲットの組織: Blood
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable