930652

Pomalidomide-C₂-NH₂ hydrochloride

≥95%

• 別名: 4-((2-aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride, 4-[(2-Aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, E3 Ligase Ligand 17
• 実験式（ヒル表記法）: C₁₅H₁₆N₄O₄ · xHCl
• CAS番号: 2305369-00-8
• 分子量: 316.31 (free base basis)
• MDL番号: MFCD31730839
• UNSPSCコード: 12352101
• NACRES: NA.21

特性

• ligand: pomalidomide
• 品質水準: 100
• アッセイ: ≥95%
• フォーム: powder
• 官能基: amine
• 保管温度: 2-8°C
• SMILES記法: O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCN)=CC=C3)=O)=O.Cl
• InChI: 1S/C15H16N4O4.ClH/c16-6-7-17-9-3-1-2-8-12(9)15(23)19(14(8)22)10-4-5-11(20)18-13(10)21;/h1-3,10,17H,4-7,16H2,(H,18,20,21);1H
• InChI Key: DSJCOXQYDMWPEY-UHFFFAOYSA-N

詳細

アプリケーション

Pomalidomide-C₂-NH₂ Hydrochloride is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Allows rapid conjugation with carboxyl linkers due to the presence of an amine group via peptide coupling reactions. It is also active for linker attachment via reductive amination, and a basic building block for development of a protein degrader library.


Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation


Protein Degrader Building Blocks

その他情報

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法的情報

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable