930075

2-fluoro-6-(pyrimidin-5-yl)aniline

≥95%

• 実験式（ヒル表記法）: C₁₀H₈FN₃
• CAS番号: 1697040-97-3
• 分子量: 189.19
• UNSPSCコード: 12352106
• NACRES: NA.06

特性

• 品質水準: 100
• アッセイ: ≥95%
• フォーム: powder, crystals or chunks
• 色: light yellow
• 官能基: fluoro
• 保管温度: −20°C
• SMILES記法: NC1=C(C2=CN=CN=C2)C=CC=C1F
• InChI: 1S/C10H8FN3/c11-9-3-1-2-8(10(9)12)7-4-13-6-14-5-7/h1-6H,12H2

詳細

アプリケーション

2-fluoro-6-(pyrimidin-5-yl)aniline is a temporary directing group (TDG) to assist as a co-catalyst for metal catalyzed C-H functionalization. Often in C-H functionalization, an auxiliary compound is used to control site selectivity. These traditionally are covalently bonded to the compound of interest, and must subsequently be removed after functionalization, like a typical protecting group. To simplify the process of C-H functionalization, 2-fluoro-6-(pyrimidin-5-yl)aniline is one of a series of temporary directing groups developed by Deb Maiti′s lab that promote site selectivity without the inclusion of additional synthetic steps.


2-fluoro-6-(pyrimidin-5-yl)aniline is an effective TDG for meta directed C-H functionalization of aldehyde substituted target compounds, with high selectivity.

その他情報

1. Imine as a linchpin approach for meta-C–H functionalization2. Transient directing ligands for selective metal-catalysed C–H activation

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable