902314

[CpRu(Fmoc-tyrosin)]CF₃CO₂

• 別名: Fmoc-protected ruthenium tyrosine amino acid derivative, Peptide radiolabel precursor, [18F]Fluorophenylalanine peptide residue precursor
• 実験式（ヒル表記法）: C₃₁H₂₆F₃NO₇Ru
• 分子量: 682.61
• UNSPSCコード: 12352209
• NACRES: NA.26

特性

• フォーム: powder
• 反応適合性: reaction type: Fmoc solid-phase peptide synthesis
• mp: >300 °C
• アプリケーション: peptide synthesis
• 官能基: Fmoc
• 保管温度: 2-8°C
• SMILES記法: O[C]1[CH][CH][C](CC(NC(OCC2C(C=CC=C3)=C3C4=C2C=CC=C4)=O)C(O)=O)[CH][CH]1.F[C-](F)F.O=C=O.[Ru+].c5cccc5

詳細

アプリケーション

The Ritter lab has developed a new method for direct labeling of polypeptides with the [18F]fluoride radiolabel. This Fmoc-protected ruthenium tyrosine is first incorporated into peptides, which is amenable to standard solid-phase peptide synthesis (SPPS) and is tolerant of all 20 canonical amino acids. Subsequent replacement of a single hydrogen with fluorine-18, with only minimal perturbation of the peptide structure, results in a site-specific, radiolabeled peptide tracer for use with positron emission tomography (PET) imaging in the study of various biological applications.

注意

Research quantities limited to 10 g.

その他情報

Site-SpecificDeoxyfluorination of Small Peptides with [18F]Fluoride

法的情報

Patent Application EP18204755.5
This product is manufactured pursuant to a license with Studiengesellschaft Kohle mbH

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable