792373

2-Chloro-2,2-difluoroacetophenone

95%

• 別名: 2-Chloro-2,2-difluoro-1-phenylethanone, Chlorodifluoromethyl phenyl ketone, α-Chloro-α,α-difluoroacetophenone
• 化学式: C₆H₅COCF₂Cl
• CAS番号: 384-67-8
• 分子量: 190.57
• Beilstein: 2251448
• MDL番号: MFCD00042123
• UNSPSCコード: 12352101
• PubChem Substance ID: 329768330
• NACRES: NA.22

特性

• 品質水準: 100
• アッセイ: 95%
• フォーム: liquid
• 反応適合性: reaction type: C-C Bond Formation
• 屈折率: n20/D 1.4954; n20/D 1.497 (lit.)
• bp: 94-96 °C/35 mmHg (lit.)
• 密度: 1.293 g/mL at 25 °C (lit.); 1.3178 g/mL at 25 °C
• 官能基: chloro; fluoro; ketone; phenyl
• SMILES記法: FC(F)(Cl)C(=O)c1ccccc1
• InChI: 1S/C8H5ClF2O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5H
• InChI Key: MNOONJNILVDLSW-UHFFFAOYSA-N

詳細

詳細

2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem -difluoromethene derived compounds.

アプリケーション

2-Chloro-2,2-difluoroacetophenone can be used:

• As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
• As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
• As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.

Reagent is an effective product for the synthesis of difluoromethylated phenols in the presence of mild base and aqueous solvent.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315,H319,H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): 160.0 °F
• 引火点(℃): 71.1 °C