197343

メチルリチウム 溶液

1.6 M in diethyl ether

• 別名: MeLi, リチウムメタニド
• 実験式（ヒル表記法）: CH₃Li
• CAS番号: 917-54-4
• 分子量: 21.98
• Beilstein: 3587162
• MDL番号: MFCD00008253
• UNSPSCコード: 12352103
• PubChem Substance ID: 24851824
• NACRES: NA.22

特性

• 蒸気密度: 3 (vs air)
• 品質水準: 100
• フォーム: liquid
• 組成: halide, ~0.05 M
• 濃度: 1.6 M in diethyl ether
• 密度: 0.732 g/mL at 25 °C
• 保管温度: 2-8°C
• SMILES記法: [Li]C
• InChI: 1S/CH3.Li/h1H3;
• InChI Key: DVSDBMFJEQPWNO-UHFFFAOYSA-N

詳細

詳細

Methyllithium is an organolithium reagent mainly used for deprotonation and as a source of methyl anion. It is a strong base and a strong nucleophile.

アプリケーション

Methyllithium solution (1.6M in diethyl ether) has been used for the asymmetric allylic alkylation (AAA) of allylic electrophiles in the presence of a chiral copper catalyst. This protocol leads to the C-C bond formation of tertiary and quaternary stereogenic centers with high enantioselectivity. It can also be used for the synthesis of (−)-salsolidine by reacting with 6,7-dimethoxy-3,4-dihydroisoquinoline in the presence of (−)-sparteine as a chiral ligand.

包装

The 25 mL Sure/Seal^™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

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法的情報

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

安全性情報

• ピクトグラム: GHS02,GHS05,GHS07
• シグナルワード: Danger
• 危険有害性情報: H225,H250,H260,H302,H314,H336
• 注意書き: P210 - P222 - P223 - P231 + P232 - P370 + P378 - P422
• 危険有害性の分類: Acute Tox. 4 Oral - Flam. Liq. 2 - Pyr. Liq. 1 - Skin Corr. 1B - STOT SE 3 - Water-react 1
• 補足的ハザード: EUH019,EUH066
• 保管分類コード: 4.2 - Pyrophoric and self-heating hazardous materials
• WGK: WGK 1
• 引火点(°F): 1.4 °F - closed cup
• 引火点(℃): -17 °C - closed cup