NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
別名:
GCCR, GCR, GR, GRL
Species:
Human NR3C1 (2908), Mouse Nr3c1 (14815), Rat Nr3c1 (24413), Zebrafish nr3c1 (553740), chicken NR3C1 (416343), dog NR3C1 (478047), domestic cat NR3C1 (692348), cow NR3C1 (281946), Horse NR3C1 (100061217), domestic cat NR3C1 (101080939) ...詳細
UniProtKB ID:
遺伝子ID:
- Human(2908) Summary: This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
- Mouse(14815) nuclear receptor subfamily 3, group C, member 1
- Rat(24413) nuclear receptor subfamily 3, group C, member 1
- Zebrafish(553740) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- chicken(416343) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- dog(478047) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- domestic cat(692348) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- cow(281946) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- Horse(100061217) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- domestic cat(101080939) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- domestic guinea pig(100135583) nuclear receptor subfamily 3, group C, member 1
- naked mole-rat(101722101) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- Domestic Rabbit(100008890) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
- sheep(443412) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
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Small Molecule - Activator
Small Molecule - Agonist
製品番号
詳細
Species
コルチゾール 溶液, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Small Molecule - Antagonist
製品番号
詳細
Species
Antibodies
製品番号
詳細
交差性
アプリケーション
抗GR ウサギ宿主抗体, affinity isolated antibody,
交差性
human, mouse, rat
アプリケーション
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
抗NR3C1 ウサギ宿主抗体, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunofluorescence
western blot
western blot
Anti-phospho-Glucocorticoid receptor Antibody, Ser226, from rabbit, purified by affinity chromatography,
交差性
human, mouse, rat
アプリケーション
western blot
Anti-Glucocorticoid Receptor Antibody, serum, from rabbit,
交差性
bovine, canine, feline, horse, human, mouse, nonhuman primates
アプリケーション
affinity binding assay
western blot
western blot
Anti-Glucocorticoid Receptor (Ab-2) Mouse mAb (BuGR2), lyophilized, clone BuGR2, Calbiochem®,
交差性
guinea pig, mouse, rabbit, rat, sheep
アプリケーション
Small Molecule - Mixed Agonist/Antagonist
製品番号
詳細
Species
デキサメタゾン, powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC),
Species
mouse, rat, human