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Merck

MMP14

matrix metallopeptidase 14 (membrane-inserted)

別名:
MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, MTMMP1
Species:
UniProtKB ID:
遺伝子ID:
  • Human(4323) Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]
  • Mouse(17387) matrix metallopeptidase 14 (membrane-inserted)
  • Rat(81707) matrix metallopeptidase 14 (membrane-inserted)
  • chicken(426253) matrix metallopeptidase 14 (membrane-inserted)
  • cow(281915) matrix metallopeptidase 14 (membrane-inserted)
  • Horse(100034170) matrix metallopeptidase 14 (membrane-inserted)
  • domestic cat(101089776) matrix metallopeptidase 14 (membrane-inserted)
  • dog(403823) matrix metallopeptidase 14 (membrane-inserted)
  • naked mole-rat(101723795) matrix metallopeptidase 14 (membrane-inserted)
  • Domestic Rabbit(100009598) matrix metallopeptidase 14 (membrane-inserted)
  • domestic guinea pig(100732039) matrix metallopeptidase 14 (membrane-inserted)
  • sheep(443116) matrix metallopeptidase 14 (membrane-inserted)

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Antibodies

Product Number
詳細
交差性
アプリケーション
抗MMP-14抗体、触媒ドメイン、クローンLEM-2/15.8, clone LEM-2/15.8, Chemicon®, from mouse,
交差性
human, mouse
アプリケーション
ELISA
immunoprecipitation (IP)

western blot
Anti-MMP-14 Antibody, serum, Chemicon®,
交差性
human
アプリケーション
ELISA
flow cytometry

immunocytochemistry

immunoprecipitation (IP)

western blot
Anti-Human MT1-MMP catalytic domain Antibody, clone 3G4.2, clone 3G4.2, Chemicon®, from mouse,
交差性
human
アプリケーション
immunocytochemistry
immunohistochemistry

western blot
Anti-MT1-MMP Antibody, hinge region, from rabbit, purified by affinity chromatography,
交差性
human, rat
アプリケーション
immunohistochemistry
western blot
抗MMP-14 ウサギ宿主抗体, affinity isolated antibody,
交差性
human, mouse, rat
アプリケーション
ELISA
immunohistochemistry

western blot

Small Molecule - Inhibitor

Product Number
詳細
Species
マリマスタット, ≥98% (HPLC),
Species
human, rat, mouse
CP-101537, ≥98% (HPLC),
Species
human, rat, mouse
CP-471474, ≥98% (HPLC),
Species
human, rat, mouse
PD166793 水和物, ≥98% (HPLC),
Species
human, rat, mouse

Proteins

Product Number
詳細
Species
MMP-14, human, prodomain, catalytic domain, and hemopexin domain, E. coli recombinant, ,
Species
human

esiRNA

Product Number
詳細
Species
MISSION® esiRNA, targeting human MMP14,
Species
human
MISSION® esiRNA, targeting mouse Mmp14,
Species
mouse