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Merck

GRM1

glutamate receptor, metabotropic 1

別名:
GPRC1A, MGLU1, MGLUR1, SCAR13
Species:
UniProtKB ID:
遺伝子ID:
  • Human(2911) Summary: This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
  • Mouse(14816) glutamate receptor, metabotropic 1
  • Rat(24414) glutamate receptor, metabotropic 1
  • domestic guinea pig(100730891) glutamate receptor, metabotropic 1
  • naked mole-rat(101712477) glutamate receptor, metabotropic 1
  • Domestic Rabbit(100356201) glutamate receptor, metabotropic 1
  • Zebrafish(100150246) glutamate receptor, metabotropic 1
  • dog(484024) glutamate receptor, metabotropic 1
  • domestic cat(101094104) glutamate receptor, metabotropic 1
  • cow(540485) glutamate receptor, metabotropic 1
  • Horse(100060603) glutamate receptor, metabotropic 1
  • chicken(421614) glutamate receptor, metabotropic 1

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Small Molecule - Agonist

製品番号
詳細
Species
(S)-3,5-ジヒドロキシフェニルグリシン 水和物, ≥98% (HPLC), powder,
Species
human
イボテン酸, ~95%, solid,
Species
rat
D-2-Aminoadipic acid, ,
Species
rat
L-2-アミノアジピン酸, ≥98% (TLC),
Species
rat, human
キスカル酸, powder,
Species
rat

Small Molecule - Antagonist

製品番号
詳細
Species
(+)-α-メチル-4-カルボキシフェニルグリシン, solid,
Species
rat
SIB 1757, ≥99% (HPLC), crystalline,
Species
human
AIDA, solid,
Species
rat, human
SIB 1893, >99%, solid,
Species
human
D-2-Aminoadipic acid, ,
Species
rat

Antibodies

製品番号
詳細
交差性
アプリケーション
モノクロナール抗グルタメート マウス宿主抗体, clone GLU-4, ascites fluid,
交差性
wide range
アプリケーション
ELISA
Anti-GRM1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunohistochemistry
Anti-Metabotropic Glutamate Receptor 1α Antibody, pain, CT, Chemicon®, from rabbit,
交差性
human, monkey, rat
アプリケーション
immunohistochemistry
western blot
Anti-Metabotropic Glutamate Receptor 1 Antibody, Chemicon®, from rabbit,
交差性
human
アプリケーション
immunohistochemistry
Anti-mGluR1 Antibody, Upstate®, from rabbit,
交差性
rat
アプリケーション
western blot

Small Molecule - Inhibitor

製品番号
詳細
Species
L-2-アミノアジピン酸, ≥98% (TLC),
Species
rat, human
キスカル酸, powder,
Species
rat
L-(+)-2-アミノ-4-ホスホノ酪酸, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human
(アミノメチル)ホスホン酸, 99%,
Species
rat, human
L-グルタミン酸, ReagentPlus®, ≥99% (HPLC),
Species
rat, human

Small Molecule - Mixed Agonist/Antagonist

製品番号
詳細
Species
L-(+)-2-アミノ-4-ホスホノ酪酸, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human
(±)-AMPA, solid,
Species
rat
L-グルタミン酸, ReagentPlus®, ≥99% (HPLC),
Species
rat, human
L-グルタミン酸, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Species
rat, human
L-グルタミン酸, BioUltra, ≥99.5% (NT),
Species
rat, human

esiRNA

製品番号
詳細
Species
MISSION® esiRNA, targeting mouse Grm1,
Species
mouse
MISSION® esiRNA, targeting human GRM1,
Species
human