Q2128

キスカル酸

powder

• 別名: β-(3,5-ジオキソ-1,2,4-オキサジアゾリジン-2-イル)-L-アラニン, 3-(3,5-ジオキソ-1,2,4-オキサジアゾリジン-2-イル)-L-アラニン
• 実験式（ヒル表記法）: C₅H₇N₃O₅
• CAS番号: 52809-07-1
• 分子量: 189.13
• Beilstein: 1078734
• MDL番号: MFCD00069337
• UNSPSCコード: 12352106
• PubChem Substance ID: 24278004
• NACRES: NA.32

特性

• フォーム: powder
• 品質水準: 200
• 色: white to off-white
• 溶解性: ethanol: <0.17 mg/mL; H₂O: 0.5 mg/mL; 0.1 M HCl: 1.4 mg/mL; 1 M NH4OH: 20 mg/mL; organic solvents: insoluble
• 保管温度: 2-8°C
• SMILES記法: N[C@@H](CN1OC(=O)NC1=O)C(O)=O
• InChI: 1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
• InChI Key: ASNFTDCKZKHJSW-REOHCLBHSA-N
• 遺伝子情報: rat ... Gria1(50592) , Grik1(29559) , Grin2a(24409) , Grm1(24414) , Grm2(24415) , Grm4(24417) , Grm5(24418)

詳細

詳細

Quisqualate/ Quisqualic acid is obtained from the fruits and seeds of Quisqualis chinensis. It is an agonist at two subsets of excitatory amino acid receptors metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores and, ionotropic receptors that directly control membrane channels. L-quisqualic acid is an agonist of the neurotransmitter L-glutamate.

アプリケーション

Quisqualic acid has also been used as a group I metabotropic receptor agonist in neurons.

Quisqualic acid has been used to test ligand-gated receptors in spiral ganglion neurons.

生物化学的／生理学的作用

キスカル酸の活性エナンチオマ-で、グルタミン酸受容体での興奮性アミノ酸です。

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves