S9311

SIB 1893

>99%, solid

• 別名: [E]-2-Methyl-6-[2-phenylethenyl]pyridine
• 実験式（ヒル表記法）: C₁₄H₁₃N
• CAS番号: 7370-21-0
• 分子量: 195.26
• MDL番号: MFCD02262120
• UNSPSCコード: 12352200
• PubChem Substance ID: 24278718
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: >99%
• 形状: solid
• 溶解性: DMSO: 18 mg/mL
• 保管温度: 2-8°C
• SMILES記法: Cc1cccc(\C=C\c2ccccc2)n1
• InChI: 1S/C14H13N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-11H,1H3/b11-10+
• InChI Key: SISOFUCTXZKSOQ-ZHACJKMWSA-N
• 遺伝子情報: human ... GRM1(2911) , GRM5(2915)

詳細

アプリケーション

SIB 1893 may be used in mGluR5 metabotropic glutamate receptor-mediated cell signaling studies.

生物化学的／生理学的作用

SIB 1893 non-competitively inhibits glutamate-induced increase in Ca²⁺ at human metabotropic glutamate receptor 1 (hmGluR1).¹ It also acts as a positive allosteric modulator of hmGluR4.²

Selective and noncompetitive mGlu₅ metabotropic glutamate receptor antagonist.

特徴および利点

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H315 - H319 - H335
• 注意書き: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves