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Merck

GRIN2C

glutamate receptor, ionotropic, N-methyl D-aspartate 2C

別名:
GluN2C, NMDAR2C, NR2C
Species:
UniProtKB ID:
遺伝子ID:
  • Human(2905) Summary: This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
  • Mouse(14813) glutamate receptor, ionotropic, NMDA2C (epsilon 3)
  • Rat(24411) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • sheep(101102915) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • domestic guinea pig(100721967) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • naked mole-rat(101698922) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • chicken(431090) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • dog(483302) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • cow(535158) glutamate receptor, ionotropic, N-methyl D-aspartate 2C
  • domestic cat(101091740) glutamate receptor, ionotropic, N-methyl D-aspartate 2C

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Small Molecule - Agonist

製品番号
詳細
Species
L-チロシン 塩酸塩, ≥98% (TLC),
Species
mouse, rat, human
D-シクロセリン, synthetic,
Species
human
N-メチル-D-アスパラギン酸, ≥98% (TLC), solid,
Species
human, rat
D-シクロセリン, ,
Species
human, mouse, rat
N-アセチル-Asp-Glu, ≥97% (TLC),
Species
mouse, human, rat

Small Molecule - Allosteric Modulator

製品番号
詳細
Species
アカンプロサートカルシウム, ≥98% (HPLC), powder,
Species
human
アカンプロサートカルシウム, United States Pharmacopeia (USP) Reference Standard, monograph mol wt. 400.48 (C10H20CaN2O8S2),
Species
human
アカンプロサートカルシウム, British Pharmacopoeia (BP) Reference Standard,
Species
human

Small Molecule - Antagonist

製品番号
詳細
Species
D(−)-2-アミノ-5-ホスホノペンタン酸, NMDA receptor antagonist,
Species
mouse, rat
イフェンプロジル (+)-酒石酸塩, ,
Species
human
Arcaine sulfate salt, ,
Species
human
(±)-2-アミノ-4-ホスホノ酪酸, solid,
Species
rat, human
(±)-CPP, solid,
Species
rat, human

Antibodies

製品番号
詳細
交差性
アプリケーション
Anti-GRIN2C antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
交差性
human
アプリケーション
western blot
Anti-NMDAR2C Antibody, also recognizes NMDAR2A and 2B, Chemicon®, from rabbit,
交差性
rat
アプリケーション
immunoprecipitation (IP)
western blot
抗グルタミン酸レセプターNMDAR2C (NR2C) ウサギ宿主抗体, affinity isolated antibody, lyophilized powder,
交差性
human, mouse, rat
アプリケーション
immunofluorescence
immunohistochemistry

immunoprecipitation (IP)

western blot

Small Molecule - Blocker

製品番号
詳細
Species
N-(3,3-Diphenylpropyl)glycinamide, >98% (HPLC), solid,
Species
human
アグマチン 硫酸塩, ≥97%, powder,
Species
human
Orphenadrine hydrochloride, ≥98.0% (AT),
Species
human
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human
Orphenadrine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Inhibitor

製品番号
詳細
Species
ペンタミジン イセチオン酸塩, powder,
Species
human
Orphenadrine hydrochloride, ≥98.0% (AT),
Species
human
Orphenadrine for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human
Orphenadrine hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human

esiRNA

製品番号
詳細
Species
MISSION® esiRNA, targeting human GRIN2C,
Species
human