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Key Documents

Altri documenti

T1408

Sigma-Aldrich

holo-Transferrin bovine

Sinonimo/i:

Siderophilin, Siderophilin, iron-saturated

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About This Item

Numero CAS:
11096-37-0
Numero CE:
234-318-8
Numero MDL:
MFCD00131337
Codice UNSPSC:
12352202
NACRES:
NA.61

Origine biologica

bovine

Saggio

97-100% (agarose gel electrophoresis)

Forma fisica

powder

tecniche

cell culture | mammalian: suitable

N° accesso UniProt

Q29443

Temperatura di conservazione

2-8°C

Informazioni sul gene

bovine ... TF(280705)

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Descrizione generale

Holo-Transferrin is an iron transporting glycoprotein and belongs to metalloprotein class. The gene encoding transferrin is mapped to bovine chromosome 1.

Applicazioni

Holo-Transferrin bovine has been used:
  • as a RPMI-1640 medium supplement for culturing cancer cell lines
  • as a component of visceral fat differentiation medium for the pre-adipocytes primary cell culture
  • to test the influence of iron-saturation complex on the growth of Malassezia pachydermatis
  • as a standard for strong anion exchange (SAX) reactor measurements

Azioni biochim/fisiol

Holo-Transferrin (holo-Tf) or the iron bound transferrin functions as an iron sequester and is crucial for defense against microbial infections. Transferrin is used as a model system for understanding the kinetics and dynamics of protein structure based interactions. It is a potential candidate for delivery studies for its ability to cross the blood-brain barrier. The interaction of holo-Tf with thrombin is implicated in the pathogenesis of intracerebral hemorrhage. Polymorphisms in the bovine transferrin gene has led to the generation of 10 variant transferrin protein.
Studies show that treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron.

Risultati analitici

Purity by agarose gel electrophoresis.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Sigma-Aldrich

Sigma-Aldrich

I0516

Insulina

Transferrina from human serum

Roche

10652202001

Transferrina

Sodium azide ≥99%, ultra dry

Sigma-Aldrich

769320

Sodium azide

Bovine and canine transferrin inhibit the growth of Malassezia pachydermatis in vitro
Bond R, et al.
Medical Mycology, 43(5), 447-451 (2005)
N P Singh et al.
Life sciences, 70(1), 49-56 (2002-01-05)
Artemisinin becomes cytotoxic in the presence of ferrous iron. Since iron influx is high in cancer cells, artemisinin and its analogs selectively kill cancer cells under conditions that increase intracellular iron concentrations. We report here that after incubation with holotransferrin
New ammunition for the proteomic reactor: strong anion exchange beads and multiple enzymes enhance protein identification and sequence coverage
Zhou H, et al.
Analytical and Bioanalytical Chemistry, 397(8), 3421-3430 (2010)
Dynamics of iron release from transferrin N-lobe studied by electrospray ionization mass spectrometry
Gumerov DR and Kaltashov IA
Analytical Chemistry, 73(11), 2565-2570 (2001)
A single nucleotide polymorphism in the coding region of bovine transferrin is associated with milk fat yield
Sanz A, et al.
Genetics and molecular research : GMR, 9(2), 843-848 (2010)
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