SRP6518

Plasminogen from human plasma

≥95% (SDS-PAGE)

• Sinonimo/i: PLG
• Codice UNSPSC: 12352202
• NACRES: NA.32

Proprietà

• Origine biologica: human
• Saggio: ≥95% (SDS-PAGE)
• Stato: lyophilized
• PM: 90.0 – 92.0 kDa
• Confezionamento: pkg of 1 mg
• N° accesso UniProt: P00747
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• Informazioni sul gene: human ... PLG(5340)

Descrizione

Descrizione generale

Plasminogen is the inactive precursor of plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration.
Plasminogen is encoded by the gene mapped to human chromosome 6q26–27. The encoded protein is characterized with a leader, kringle and protease domains.

Azioni biochim/fisiol

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. It cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. Plasmin is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β).

Stato fisico

Lyophilized from 20 mM Tris-HCl, pH 7.5, with 2 mM EDTA.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable