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Key Documents

SAB4502329

Sigma-Aldrich

Anti-AMPK α antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

5′-AMP-activated protein kinase, AAPK1, AMPK α-1 chain, AMPK-α1, catalytic α-1 chain

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 62 kDa

Reattività contro le specie

rat, mouse, human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

N° accesso NCBI

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... AAPK1(5562)

Descrizione generale

Anti-AMPK α antibody detects endogenous levels of total AMPK α protein.
The AMPK α (protein kinase AMP-activated catalytic subunit α1) gene is located on human chromosome 5p13.1. The gene is evolutionarily conserved.

Immunogeno

The antiserum was produced against synthesized peptide derived from human AMPK alpha.

Immunogen Range: 140-189

Applicazioni

Anti-AMPK α antibody produced in rabbit has been used in immunohistochemistry.

Azioni biochim/fisiol

The AMPK α (protein kinase AMP-activated catalytic subunit α1) gene is associated with the regulation of cell cycle, cell proliferation, energy metabolism and inhibition of rapamycin-pathway. Therefore, it plays an important role in carcinogenesis. From recent studies, variation in the gene is known to be involved in gastric cancer. AMPK α might induce anti-inflammatory response in adipose tissue, upon its activation resulting in a beneficial effect in obesity. Decreased cellular ATP or AMP is known to stimulate AMPK enzyme. Activated AMPK stimulates pathways such as mitochondrial biogenesis, glucose transport in muscle and mitochondrial biogenesis, in order to replenish cellular ATP. On the other hand, it prevents anabolic pathways that consume ATP including biosynthesis of fatty acid and cholesterol as well as adipogenesis. The AMPK signaling pathway is generally stimulated in response to stress, energy deficiency and/or oxygen inadequacy.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Articoli

We present an article about how proliferating cells require the biosynthesis of structural components for biomass production and for genomic replication.

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

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