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P7045

Supelco

Phenformin hydrochloride

analytical standard

Sinonimo/i:

N-(2-Phenylethyl)imidodicarbonimidic diamide monohydrochloride, Phenethylbiguanide

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About This Item

Formula empirica (notazione di Hill):
C10H15N5 · HCl
Numero CAS:
834-28-6
Peso molecolare:
241.72
Numero CE:
212-637-3
Numero MDL:
MFCD00035039
Codice UNSPSC:
41116107
ID PubChem:
329820259
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

100

tecniche

HPLC: suitable
gas chromatography (GC): suitable

applicazioni

forensics and toxicology
pharmaceutical (small molecule)

Formato

neat

Stringa SMILE

Cl.NC(=N)NC(=N)NCCc1ccccc1

InChI

1S/C10H15N5.ClH/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8;/h1-5H,6-7H2,(H6,11,12,13,14,15);1H
YSUCWSWKRIOILX-UHFFFAOYSA-N

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Categorie correlate

Descrizione generale

Phenformin hydrochloride is a biguanide derivative that shows anti-diabetic activity.

Applicazioni

Phenformin hydrochloride has been used as a test compound to study the antineoplastic activity it can exhibit in suppressing the growth of ovarian cancer cells and also human hepatocellular carcinoma cells.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
MKCQ6399
MKCM5853
MKCJ5461
MKCF2089
MKCD3844

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Anti-AMPK α antibody produced in rabbit affinity isolated antibody

Sigma-Aldrich

SAB4502329

Anti-AMPK α antibody produced in rabbit

Metformin hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1396309

Metformin hydrochloride

Metformin hydrochloride solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Supelco

M-072

Metformin hydrochloride solution

Dorsomorphin ≥98% (HPLC)

Sigma-Aldrich

P5499

Dorsomorphin

Myxothiazol from Myxococcus fulvus Mx f85, ≥98% (HPLC)

Sigma-Aldrich

T5580

Myxothiazol

Metformin hydrochloride British Pharmacopoeia (BP) Reference Standard

BP227

Metformin hydrochloride

Energy metabolism determines the sensitivity of human hepatocellular carcinoma cells to mitochondrial inhibitors and biguanide drugs
Hsu C-C, et al.
Oncology Reports, 34(3), 1620-1628 (2015)
Relevance of the OCT1 transporter to the antineoplastic effect of biguanides
Segal D E, et al.
Biochemical and Biophysical Research Communications, 414(4), 694-699 (2011)
Ashley J Ovens et al.
The Biochemical journal, 479(11), 1181-1204 (2022-05-14)
The AMP-activated protein kinase (AMPK) αβγ heterotrimer is a primary cellular energy sensor and central regulator of energy homeostasis. Activating skeletal muscle AMPK with small molecule drugs improves glucose uptake and provides an opportunity for new strategies to treat type
Arindam Mondal et al.
Scientific reports, 12(1), 13135-13135 (2022-07-31)
The imidazolium compound Ym155 was first reported to be a survivin inhibitor. Ym155 potently induces cell death of many types of cancer cells in preclinical studies. However, in phase II clinical trials Ym155 failed to demonstrate a significant benefit. Studies
Mozhgan Sedigh-Ardekani et al.
Regulatory toxicology and pharmacology : RTP, 70(2), 514-518 (2014-09-10)
Lactic acidosis occurs in a number of clinical conditions, e.g. in surgeries, orthotopic liver transplant, and anesthetic agent administration, which has deleterious effects on the patient's survival. The most rational therapy for these patients, the sodium bicarbonate administration, cannot prevent
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