Passa al contenuto
Merck
Tutte le immagini(1)

Key Documents

View All Documentation

P2371

Sigma-Aldrich

Pamidronate disodium salt hydrate

≥95% (NMR), solid

Sinonimo/i:

3-Amino-1-hydroxy-1-phosphonopropanephosphonic acid disodium salt hydrate

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C3H9NO7P2Na2 · xH2O
Numero CAS:
57248-88-1
Peso molecolare:
279.03 (anhydrous basis)
Numero CE:
260-647-1
Numero MDL:
MFCD11045314
Codice UNSPSC:
12352200
ID PubChem:
24724574
NACRES:
NA.77

Saggio

≥95% (NMR)

Forma fisica

solid

Colore

white

Punto di fusione

300 °C

Solubilità

H2O: 28 mg/mL

Ideatore

Novartis

Temperatura di conservazione

2-8°C

Stringa SMILE

O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O

InChI

1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2
TVQNUQCYOOJTMK-UHFFFAOYSA-L

Azioni biochim/fisiol

Pamidronate disodium has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.
Bone resorption inhibitor; inhibitor of farnesyl diphosphate synthase (IC50 = 200 nM).

Caratteristiche e vantaggi

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 10

1 of 10

Alendronate sodium United States Pharmacopeia (USP) Reference Standard

USP

1012780

Alendronate sodium

Dichloromethylenediphosphonic acid disodium salt

Sigma-Aldrich

D4434

Dichloromethylenediphosphonic acid disodium salt

Sodium alendronate trihydrate European Pharmacopoeia (EP) Reference Standard

Y0001727

Sodium alendronate trihydrate

Risedronate sodium ≥97% (HPLC)

Sigma-Aldrich

SML0650

Risedronate sodium

Alendronate, Sodium Salt An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction.

Sigma-Aldrich

126855

Alendronate, Sodium Salt

SR 12813 ≥98%, solid

Sigma-Aldrich

S4194

SR 12813

6-Fluoromevalonate ≥90% (GC), viscous liquid

Sigma-Aldrich

F2929

6-Fluoromevalonate

C10 bisphosphonate Avanti Research™ - A Croda Brand 860480P, powder

Avanti

860480P

C10 bisphosphonate

Sodium alendronate British Pharmacopoeia (BP) Reference Standard

BP830

Sodium alendronate

Tiludronate disodium salt hydrate ≥98% (HPLC)

Sigma-Aldrich

T4580

Tiludronate disodium salt hydrate

Uncomplicated vaginal delivery in two consecutive pregnancies carried to term in a woman with osteogenesis imperfecta type I and bisphosphonate treatment before conception.
Chih-Ping Chen et al.
Taiwanese journal of obstetrics & gynecology, 51(2), 305-307 (2012-07-17)
Alexandre Loupy et al.
The Journal of clinical investigation, 122(9), 3355-3367 (2012-08-14)
Tight regulation of calcium levels is required for many critical biological functions. The Ca2+-sensing receptor (CaSR) expressed by parathyroid cells controls blood calcium concentration by regulating parathyroid hormone (PTH) secretion. However, CaSR is also expressed in other organs, such as
Coralie Leblicq et al.
Pediatric blood & cancer, 60(5), 741-747 (2012-09-25)
Osteonecrosis (ON) is a severe complication of acute lymphoblastic leukemia (ALL) treatments. Recent studies suggest that bisphosphonates might reduce pain and loss of motor function in patients with ON. We assessed the effects of pamidronate compared to standard care in
Pamidronate decreases bilirubin-impaired cell death and improves dentinogenic dysfunction of stem cells from human deciduous teeth
Yamaza H, et al.
Stem Cell Research & Therapy, 9(1), 303-303 (2018)
Pamidronate Disodium Leads to Bone Necrosis via Suppression of Wnt/beta-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells In Vitro
Xu Y, et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 75(10), 2135-2143 (2017)
Visualizza tutti i documenti correlati

Contenuto correlato

Discover Bioactive Small Molecules for Cyclic Nucleotides

Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. cAMP modifies cell function in all eukaryotic cells, principally through the activation of cAMP-dependent protein kinase (PKA), but also through cAMP-gated ion channels and guanine nucleotide exchange factors directly activated by cAMP.

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.