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D4434

Sigma-Aldrich

Dichloromethylenediphosphonic acid disodium salt

Sinonimo/i:

Cl2MDP, Clodronate disodium, Clodronic acid disodium salt, DMDP

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About This Item

Formula condensata:
CH2O6Cl2Na2P2
Numero CAS:
22560-50-5
Peso molecolare:
288.86
Numero CE:
245-078-9
Numero MDL:
MFCD01632786
Codice UNSPSC:
12352106
ID PubChem:
24278371
NACRES:
NA.77

Stato

powder

Livello qualitativo

300

Solubilità

water: 49.00-51.00 mg/mL, clear, colorless

Temperatura di conservazione

room temp

Stringa SMILE

[Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O

InChI

1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
HJKBJIYDJLVSAO-UHFFFAOYSA-L

Informazioni sul gene

rat ... Man2a1(25478) , Si(497756)

Azioni biochim/fisiol

Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma. When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver. Found also to inhibit collagenase and matrix metalloproteinase1.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
049M4057V
13181128
078M4034V
017M4072V
017M4071V

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Sigma-Aldrich

L4395

Liposome Kit: Lipid mixtures for the preparation of liposomes

N-Methyl-D-aspartic acid ≥98% (TLC), solid

Sigma-Aldrich

M3262

N-Methyl-D-aspartic acid

L-α-fosfatidilcolina egg yolk, Type XVI-E, ≥99% (TLC), lyophilized powder

Sigma-Aldrich

P3556

L-α-fosfatidilcolina

Fabricio Montalvao et al.
The Journal of clinical investigation, 123(12), 5098-5103 (2013-11-02)
Anti-CD20 Ab therapy has proven successful for treating B cell malignancies and a number of autoimmune diseases. However, how anti-CD20 Abs operate in vivo to mediate B cell depletion is not fully understood. In particular, the anatomical location, the type
A Lipton
Cancer, 80(8 Suppl), 1668-1673 (1997-11-15)
The skeleton is a common site of breast carcinoma metastasis; 75% of patients with breast carcinoma demonstrate bone metastases at autopsy. The lytic destruction of bone in these patients is due to excessive osteoclastic activity. By reducing osteoclastic activity, bisphosphonates
H A Fleisch
Annals of medicine, 29(1), 55-62 (1997-02-01)
The bisphosphonates are synthetic compounds characterized by a P-C-P bond. They have a strong affinity to calcium phosphates and hence to bone mineral. In vitro they inhibit both formation and dissolution of the latter. Many of the bisphosphonates inhibit bone
O Teronen et al.
Calcified tissue international, 61(1), 59-61 (1997-07-01)
Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 microM. These findings suggest an
Michiko Itoh et al.
PloS one, 8(12), e82163-e82163 (2013-12-19)
Although macrophages are thought to be crucial for the pathogenesis of chronic inflammatory diseases, how they are involved in disease progression from simple steatosis to non-alcoholic steatohepatitis (NASH) is poorly understood. Here we report the unique histological structure termed "hepatic
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