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860480P

Avanti

C10 bisphosphonate

Avanti Research™ - A Croda Brand 860480P, powder

Sinonimo/i:

1-aminodecane-1,1-bisphosphonic acid

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About This Item

Formula empirica (notazione di Hill):
C10H25NO6P2
Numero CAS:
15049-93-1
Peso molecolare:
317.26
Codice UNSPSC:
12352211
NACRES:
NA.25

Stato

powder

Confezionamento

pkg of 1 × 500 μg (860480P-500ug)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand 860480P

Tipo di lipide

bioactive lipids
sphingolipids

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

[NH3+]C(P([O-])(O)=O)(P(O)(O)=O)CCCCCCCCC

InChI

1S/C10H25NO6P2/c1-2-3-4-5-6-7-8-9-10(11,18(12,13)14)19(15,16)17/h2-9,11H2,1H3,(H2,12,13,14)(H2,15,16,17)
TWYYYYAFACTHMV-UHFFFAOYSA-N

Applicazioni

C10 bisphosphonate is suitable for use as an inhibitor for acid sphingomyelinase.

Azioni biochim/fisiol

C10 bisphosphonate, with prolonged carbon chain, is an inhibitor for acid sphingomyelinase and may be a treatment option for inflammatory lung diseases, cystic fibrosis and atherosclerosis. It interacts with the divalent metal ions and forms bidentate complexes. Bisphosphonates are inhibitors of end reaction in pathways. It is an inhibitor of cytosolic farnesyl diphosphate (FDP) synthase (geranyl diphosphate (GDP) and geranylgeranyl diphosphate (GGDP) synthase and isoprene pathway. Bisphosphonates have antimicrobial functionality and inhibits the growth of Entamoeba histolytica and Plasmodium falciparum.

Confezionamento

5 mL Amber Glass Screw Cap Vial (860480P-500ug)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number

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Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis
Novgorodov SA, et al.
Journal of Lipid Research, 59(2), 312-329 (2018)
Potent and selective inhibition of acid sphingomyelinase by bisphosphonates
Roth AG, et al.
Angewandte Chemie (International Edition in English), 48(41), 7560-7563 (2009)
Bisphosphonate inhibitors reveal a large elasticity of plastidic isoprenoid synthesis pathway in isoprene-emitting hybrid aspen
Rasulov B, et al.
Plant Physiology, 168(2), 532-548 (2015)
Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo
Ghosh S, et al.
Journal of Medicinal Chemistry, 47(1), 175-187 (2004)
Volker Teichgräber et al.
Nature medicine, 14(4), 382-391 (2008-04-01)
Microbial lung infections are the major cause of morbidity and mortality in the hereditary metabolic disorder cystic fibrosis, yet the molecular mechanisms leading from the mutation of cystic fibrosis transmembrane conductance regulator (CFTR) to lung infection are still unclear. Here
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