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M3013

Sigma-Aldrich

β-Methylcrotonyl coenzyme A lithium salt

≥90%

Sinonimo/i:

trans-3-Methyl-2-butenoyl Coenzyme A

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About This Item

Formula empirica (notazione di Hill):
C26H42N7O17P3S
Numero CAS:
108347-83-7
Peso molecolare:
849.63
Numero MDL:
MFCD00079431
Codice UNSPSC:
41106305
ID PubChem:
24896611
NACRES:
NA.51

Saggio

≥90%

Temperatura di conservazione

−20°C

Stringa SMILE

[Li].C\C(C)=C\C(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OCC1OC(C(O)C1OP(O)(O)=O)n2cnc3c(N)ncnc23

InChI

1S/C26H42N7O17P3S.Li.H/c1-14(2)9-17(35)54-8-7-28-16(34)5-6-29-24(38)21(37)26(3,4)11-47-53(44,45)50-52(42,43)46-10-15-20(49-51(39,40)41)19(36)25(48-15)33-13-32-18-22(27)30-12-31-23(18)33;;/h9,12-13,15,19-21,25,36-37H,5-8,10-11H2,1-4H3,(H,28,34)(H,29,38)(H,42,43)(H,44,45)(H2,27,30,31)(H2,39,40,41);;
LTOKXDRORBIJJG-UHFFFAOYSA-N

Applicazioni

Coenzyme A functions as an acyl group carrier, acetyl-CoA. β-Methylcrotonyl coenzyme A is used as a substrate to study the specificity and kinetics of β-methylcrotonyl-coenzyme A carboxylase (MCCase).

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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trans-2-Methyl-2-butenoyl chloride ≥97.0%

Sigma-Aldrich

688606

trans-2-Methyl-2-butenoyl chloride

Acetoacetyl coenzyme A sodium salt hydrate cofactor for acyl transfer

Sigma-Aldrich

A1625

Acetoacetyl coenzyme A sodium salt hydrate

Palmitoyl coenzyme A lithium salt ≥90%

Sigma-Aldrich

P9716

Palmitoyl coenzyme A lithium salt

Sieroalbumina heat shock fraction, pH 7, ≥98%

Sigma-Aldrich

A7906

Sieroalbumina

X. Wang et al.
Plant physiology, 108(3), 1133-1139 (1995-07-01)
Regulation of the expression of the gene(s) coding for the 78-kD, biotin-containing subunit of [beta]-methylcrotonyl-coenzyme A carboxylase (MCCase) was investigated in different organs of tomato (Lycopersicon esculantus) plants. The specific activity of MCCase is highest in extracts from roots, followed
S Aubert et al.
FEBS letters, 383(3), 175-180 (1996-04-01)
Induction of beta-methylcrotonyl-coenzyme A carboxylase (MCCase) activity was observed during carbohydrate starvation in sycamore cells. In mitochondria isolated from starved cells, we noticed a marked accumulation of the biotinylated subunit of MCCase, of which the apparent molecular weight of 74000
B Wolf et al.
Enzyme, 24(5), 302-306 (1979-01-01)
At least one arginine residue is essential for substrate binding in or near the active sites of propionyl CoA carboxylase (PCC) and beta-methylcrotonyl CoA carboxylase (beta MCC) in cultured human fibroblasts. This conclusion is based on studies of enzyme inhibition
Kiyoung Kim et al.
Life (Basel, Switzerland), 11(1) (2021-01-23)
Although mitochondrial dysfunction is associated with the development and progression of diabetic nephropathy (DN), its mechanisms are poorly understood, and it remains debatable whether mitochondrial morphological change is a cause of DN. In this study, a Drosophila DN model was
Elma Zaganjor et al.
Cell reports, 36(2), 109345-109345 (2021-07-15)
Upon nutrient stimulation, pre-adipocytes undergo differentiation to transform into mature adipocytes capable of storing nutrients as fat. We profiled cellular metabolite consumption to identify early metabolic drivers of adipocyte differentiation. We find that adipocyte differentiation raises the uptake and consumption

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