F3771

Fumonisin B₂ from Fusarium moniliforme

sphingosine N-acyltransferase inhibitor

• Sinonimo/i: FB₂, Fumonisin B₂
• Formula empirica (notazione di Hill): C₃₄H₅₉NO₁₄
• Numero CAS: 116355-84-1
• Peso molecolare: 705.83
• Numero MDL: MFCD00133350
• Codice UNSPSC: 12352202
• ID PubChem: 24894857
• NACRES: NA.77

Proprietà

• Origine biologica: Fusarium sp. (Fusarium moniliforme)
• Livello qualitativo: 100
• Saggio: ≥96% (TLC)
• Stato: powder
• Solubilità: methanol: 10 mg/mL, clear, colorless to faintly yellow
• Temperatura di conservazione: −20°C
• Stringa SMILE: CCCCC(C)C(OC(=O)CC(CC(O)=O)C(O)=O)C(CC(C)CCCCCCC(O)CC(O)C(C)N)OC(=O)CC(CC(O)=O)C(O)=O
• InChI: 1S/C34H59NO14/c1-5-6-12-21(3)32(49-31(43)18-24(34(46)47)16-29(40)41)27(48-30(42)17-23(33(44)45)15-28(38)39)14-20(2)11-9-7-8-10-13-25(36)19-26(37)22(4)35/h20-27,32,36-37H,5-19,35H2,1-4H3,(H,38,39)(H,40,41)(H,44,45)(H,46,47); UXDPXZQHTDAXOZ-UHFFFAOYSA-N

Descrizione

Descrizione generale

Fumonisin B₂ (FB₂) is a diester of tricarballylic acid and polyhydric alcohols.. Fumonisins B₂ (FB₂) does not have one or more hydroxyl groups at the C5 or C10 positions.

Mycotoxin originally isolated from Fusarium sp, which grows on corn. Produces neural tube defects and craniofacial abnormalities in fetuses. Many strains of Aspergillus niger growing naturally on grapes are capable of producing fumonisin B₂, so it is now a concern for human consumption of grapes, raisins, and wine.

Applicazioni

Fumonisin B₂ (FB₂) from Fusarium moniliforme has been used:

• as a standard for the detection of FB₂ by high performance liquid chromatography (HPLC) in corn based food products
• used as standard in the determination of fumonisin B1 and B2 in corn and corn-based products by high-performance liquid chromatography
• as a standard in the determination of mycotoxins by HPLC

Azioni biochim/fisiol

Inhibitor of sphingosine N-acyltransferase. Blocks the formation of ceramide from sphingosine.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Warning
• Indicazioni di pericolo: H351
• Consigli di prudenza: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classi di pericolo: Carc. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges