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D9260

Sigma-Aldrich

Dextran from Leuconostoc mesenteroides

average mol wt 9,000-11,000

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About This Item

Formula condensata:
(C6H10O5)n
Numero CAS:
9004-54-0
Numero CE:
232-677-5
Numero MDL:
MFCD00130935
Codice UNSPSC:
12352201
NACRES:
NA.25

Origine biologica

bacterial (Leuconostoc mesenteroides)

Livello qualitativo

200

Forma fisica

powder

Attività ottica

[α]/D 199°

PM

average mol wt 9,000-11,000

Solubilità

water: 0.1 g/mL, colorless to faintly yellow

Temperatura di conservazione

2-8°C

InChI

1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2
FZWBNHMXJMCXLU-UHFFFAOYSA-N

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Categorie correlate

Applicazioni

Dextrans are used in many applications as platelet aggregants, plasma volume extenders, osmotic pressure regulators, stabilizers, organ separation media, matrix components, copolymers, microcarriers, binding agents, viscosity modifiers, antithrombotics, lubricants and physical structure components. They may be used as long hydrophilic spacer arms to improve the performance (freedom of movement) of conjugated/bound proteins. Dextrans may be derivatized for use in biosensor systems.
Dextrans of less than 60,000Da are generally considered low molecular weight dextrans. Low molecular weight dextrans are often preferred versus high molecular weight dextrans due to their viscosities, aggregation and permeation properties. High molecular weight, water-soluble, dextran polymers have been used in a wide variety of biomedical applications. Dextran (9,000-11,000), a low molecular weight dextran, may be used to study processes such as transient plasma membrane and blood brain barrier (BBB) permeabilization. It may be used as a sugar based crowding agent in protein packing and folding studies.
Use of dextrans as long and hydrophilic spacer arms improves the performance of immobilized proteins acting on macromolecules.

Nota sulla preparazione

With the exception of the highest MW dextran, D5501 (MW range = 5 million to 40 million), dextrans are very water soluble. Sigma tests the solubility of dextrans at concentrations generally exceeding 30 mg/ml in water. Dextrans are also freely soluble in DMSO, formamide, ethylene glycol, and glycerol. Neutral-aqueous dextran solutions can be sterilized by autoclaving at 110-115oC for 30 to 45 minutes. Dextran can be hydrolyzed by strong acids at high temperatures. The terminal reducing end group of dextran can be oxidized in alkaline solutions.

Altre note

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Codice della classe di stoccaggio

11 - Combustible Solids

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Thomas Rath et al.
Nephron. Clinical practice, 114(1), c81-c88 (2009-11-06)
Intravenous iron supplementation is a basic principle in the therapy of haemodialysis (HD) patients with renal anaemia. In the Iron Dextran in Renal Anaemia (IDIRA) study, we analysed the efficacy of a therapy with low-molecular-weight iron dextran (LMW-ID) in stable
Eugen Sisu et al.
Rapid communications in mass spectrometry : RCM, 20(2), 209-218 (2005-12-15)
A combined methodology for obtaining at the preparative scale and characterization by nanoelectrospray ionization (nanoESI) quadrupole time-of-flight (QTOF) mass spectrometry (MS) and tandem MS (MS/MS) of linear polysaccharides modified at the reducing end is presented. Two polydisperse maltodextrins (1000 and
R J Stenekes et al.
Biomaterials, 22(13), 1891-1898 (2001-06-09)
In this paper, a novel method is presented for the preparation of dextran hydrogels and microspheres, based on crystallization. Although dextrans are known to be well soluble in water, precipitation was observed in concentrated aqueous solutions of low molecular weight
Diego Delgado et al.
Human gene therapy, 23(4), 345-355 (2012-02-03)
The goal of the present study was to analyze the potential application of nonviral vectors based on solid lipid nanoparticles (SLN) for the treatment of ocular diseases by gene therapy, specifically X-linked juvenile retinoschisis (XLRS). Vectors were prepared with SLN
Yuichi Ozaki et al.
Circulation journal : official journal of the Japanese Circulation Society, 76(4), 922-927 (2012-02-04)
Although an intracoronary frequency-domain optical coherence tomography (FD-OCT) system overcomes several limitations of the time-domain OCT (TD-OCT) system, the former requires injection of contrast media for image acquisition. The increased total amount of contrast media for FD-OCT image acquisition may
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Protocolli

Dextran

Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(1-6) linkages. The remaining a(1-3) linkages account for the branching of dextran. Conflicting data on the branch lengths implies that the average branch length is less than three glucose units. However, other methods indicate branches of greater than 50 glucose units exist.

Dextran Sulfate

Dextran sulfates are supplied as the sodium salt forms, making them soluble and stable in water. Dextran sulfate contains approximately 17% sulfur which is equivalent to approximately 2.3 sulfate groups per glucosyl residue.

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