C9758

L-Canavanine sulfate salt

≥99% (TLC), powder

• Sinonimo/i: L-α-Amino-γ-(guanidinooxy)butyric acid sulfate salt
• Formula empirica (notazione di Hill): C₅H₁₂N₄O₃ · H₂SO₄
• Numero CAS: 2219-31-0
• Peso molecolare: 274.25
• Beilstein: 6121291
• Numero CE: 218-728-4
• Numero MDL: MFCD00012618
• Codice UNSPSC: 12352209
• ID PubChem: 24278349
• NACRES: NA.32

Proprietà

• Origine biologica: plant seeds (Jack bean )
• Livello qualitativo: 200
• Saggio: ≥99% (TLC)
• Stato: powder
• Colore: white
• Punto di fusione: 160-165 °C (dec.)
• Solubilità: H₂O: 100 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: OS(O)(=O)=O.N[C@@H](CCONC(N)=N)C(O)=O
• InChI: 1S/C5H12N4O3.H2O4S/c6-3(4(10)11)1-2-12-9-5(7)8;1-5(2,3)4/h3H,1-2,6H2,(H,10,11)(H4,7,8,9);(H2,1,2,3,4)/t3-;/m0./s1; MVIPJKVMOKFIEV-DFWYDOINSA-N
• Informazioni sul gene: human ... NOS2(4843)

Descrizione

Descrizione generale

Canavanine is a homolog of arginine and a non-protein amino acid. It is present in plants like alfalfa, cloves, beans onions and sprouts. Canavanine is synthesized from L-canavaninosuccinic acid and the biosynthetic pathway was first elucidated in jack bean plant.

Applicazioni

Canavanine sulfate salt has been used:

• as a translation inhibitor in yeast translation studies
• as a component of synthetic complete (SC) drop-out medium for screening yeast
• for screening Saccharomyces cerevisiae in canavanine mutation frequency assay

Azioni biochim/fisiol

Canavanine is a naturally occurring L-amino acid that competes and interferes with L-arginine-utilizing enzymes due to its structural similarity with this L-amino acid. It is a selective inhibitor of inducible nitric oxide synthase (iNOS). It acts as a substrate for arginyl tRNA and is incorporated during protein synthesis leading to aberrant canavanyl proteins. Supplementation with canavanine worsens the alfalfa induced Systemic lupus erythematosus (SLE) like syndrome and its incorporation with endosome and proteasome disrupts the antigen processing.

Naturally occurring L-amino acid that interferes with L-arginine-utilizing enzymes due to its structural similarity with this L-amino acid. It is a selective inhibitor of inducible nitric oxide synthase (iNOS).

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves