C8374
Human Collagen Type IV
from human placenta, powder
Sinonimo/i:
Collagen from human placenta, Collagen Type 4
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About This Item
Prodotti consigliati
Nome del prodotto
Collagene, Bornstein and Traub Type IV, powder
Origine biologica
human placenta
Livello qualitativo
Saggio
>85% (SDS-PAGE)
Stato
powder
tecniche
cell culture | stem cell: suitable
Impurezze
HIV, hepatitis B and hepatitis C, none detected
Solubilità
0.5 M acetic acid: 1 mg/mL, clear to very slightly hazy
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... COL4A1(1282) , COL4A2(1284) , COL4A3(1285) , COL4A4(1286) , COL4A5(1287) , COL4A6(1288)
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Applicazioni
Type IV collagen has been found to play a key role in angiogenesis, neurological diseases and metastasis. Collagen from human placenta has been used to assess the bioelectric effects of quinine on airway epithelial cells, to study the selective toxicity of engineered lentvirus lytic peptides and in a particle aggregation assay for the rapid detection of fibronectin, fibrinogen and collagen receptors on Staphylococcus aureus. It has also been used in a magnesium-dependent, collagen-binding assay during characterization of human lung tumor-associated antigens.
Azioni biochim/fisiol
During development, collagen IV is ubiquitously distributed in BMs. During the maturation process, this network gets partially replaced in a remarkably tissue specific manner, defining BM structure and function. Collagen IV has been shown to bind to platelets, hepatocytes, keratinocytes, endothelial, mesangial, pancreatic cells and some tumor cells.
Tissue injury in the autoimmune disease Goodpasture syndrome is due to pathogenic autoantibodies targeting the Collagen IV α3 chain . Mutations in COL4A5 are associated with Alport syndrome.
Tissue injury in the autoimmune disease Goodpasture syndrome is due to pathogenic autoantibodies targeting the Collagen IV α3 chain . Mutations in COL4A5 are associated with Alport syndrome.
Componenti
All collagen molecules are composed of three polypeptide chains arranged in a triple helical conformation, with a primary structure that is mostly a repeating motif with glycine in every third position and proline or 4-hydroxyproline frequently preceding the glycine residue. Type IV collagen occurs only in the basement membranes and contains up to six genetically distinct a-chains.
Avvertenza
This product should be stored desiccated at -20°C, and will retain activity in these conditions for 3 years.
Nota sulla preparazione
This powder can be reconstituted in sterile .5 M acetic acid, PBS or water at 1 mg/mL. A PBS solution will be stable for at least one year at -20°C.
Risultati analitici
An SDS polyacrylamide gel electrophoresis test run under reducing conditions consistent with basement membrane collagen yields three major bands.
Altre note
Il collagene è classificato in diversi tipi strutturalmente e geneticamente distinti. Sigma utilizza la nomenclatura proposta da Bornstein e Traub. Occorre prestare attenzione a non confondere le denominazioni delle tipologie Sigma con le classificazioni del collagene universalmente riconosciute.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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