C7521
Human Collagen Type IV
from human placenta, powder, suitable for substrate for collagenase and for diagnostic assay manufacturing
Sinonimo/i:
Collagen Type 4
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About This Item
Prodotti consigliati
product name
Collagene, Bornstein and Traub Type IV, powder
Origine biologica
human placenta
Livello qualitativo
Descrizione
Sigma Type VI
Forma fisica
powder
Impurezze
HIV, hepatitis B and hepatitis C, none detected
Solubilità
0.5 M acetic acid: 1 mg/mL
Compatibilità
suitable for substrate for collagenase
applicazioni
diagnostic assay manufacturing
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... COL4A2(1284) , COL4A3(1285) , COL4A4(1286) , COL4A5(1287) , COL4A6(1288)
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Azioni biochim/fisiol
During development, collagen IV is ubiquitously distributed in BMs. During the maturation process, this network gets partially replaced in a remarkably tissue specific manner, defining BM structure and function. Collagen IV has been shown to bind to platelets, hepatocytes, keratinocytes, endothelial, mesangial, pancreatic cells and some tumor cells.
Componenti
All collagen molecules are composed of three polypeptide chains arranged in a triple helical conformation, with a primary structure that is mostly a repeating motif with glycine in every third position and proline or 4-hydroxyproline frequently preceding the glycine residue. Type IV collagen occurs only in the basement membranes and contains up to six genetically distinct a-chains.
Nota sulla preparazione
This is a lyophilized powder that can be reconstituted in sterile .5 M acetic acid, PBS or water at 1 mg/mL. A PBS solution will be stable for at least one year at -20°C. It is prepared by a modification of the pepsin extraction method of Glanville, R.W., et al.
Risultati analitici
An SDS polyacrylamide gel electrophoresis test run under reducing conditions consistent with basement membrane collagen yields three major bands.
Altre note
Il collagene è classificato in diversi tipi strutturalmente e geneticamente distinti. Sigma utilizza la nomenclatura proposta da Bornstein e Traub. Occorre prestare attenzione a non confondere le denominazioni delle tipologie Sigma con le classificazioni del collagene universalmente riconosciute.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
Certificati d'analisi (COA)
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