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Key Documents

C7642

Sigma-Aldrich

Concanavalin A from Canavalia ensiformis (Jack bean)

FITC conjugate, Type IV, lyophilized powder

Sinonimo/i:

ConA

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About This Item

Codice UNSPSC:
12352202
NACRES:
NA.32

Origine biologica

Canavalia ensiformis

Livello qualitativo

Coniugato

FITC conjugate

Tipo

Type IV

Forma fisica

lyophilized powder

Composizione

Protein, 5-15% biuret

Grado di funzionalizzazione

3-6 mol FITC per mol protein

Impurezze

Carbohydrate, essentially free

Temperatura di conservazione

−20°C

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Applicazioni

For the fluorescent detection of glycoproteins containing α−D-mannose or α−D-glucose

Azioni biochim/fisiol

Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca2+ and Mn2+ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.

Confezionamento

Package size based on protein content

Stato fisico

Lyophilized powder containing phosphate buffer salts and NaCl

Risultati analitici

Where reported, agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, containing Ca2+ and Mn2+ of a 1 mg per mL solution. This activity is the lowest concentration to agglutinate a 2% suspension of human erythrocytes after 1 hr incubation at 25 °C.

Pittogrammi

Exclamation mark

Avvertenze

Warning

Indicazioni di pericolo

Consigli di prudenza

Classi di pericolo

Skin Sens. 1

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


Certificati d'analisi (COA)

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Noninfectious (autoimmune and immune-mediated) uveitis is an ocular inflammatory disease which can lead to blindness in severe cases. Due to the potential side effects of first-line drugs for clinical uveitis, novel drugs and targets against uveitis are still urgently needed.
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Biofilms are communities of bacteria embedded in a self-produced glycocalyx matrix. Adenoids have been shown to harbor bacterial biofilms. Aim/objectives: To compare the prevalence of biofilms in adenoid of children with chronic otitis media (COM) (group1) versus a control group

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