Passa al contenuto
Merck
Tutte le immagini(1)

Key Documents

PHR1121

Supelco

2-Phenoxyethanol

Pharmaceutical Secondary Standard; Certified Reference Material

Sinonimo/i:

Ethylene glycol monophenyl ether, Phenylglycol

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali


About This Item

Formula condensata:
C6H5OCH2CH2OH
Numero CAS:
Peso molecolare:
138.16
Beilstein:
1364011
Numero CE:
Numero MDL:
Codice UNSPSC:
41116107
ID PubChem:
NACRES:
NA.24

Grado

certified reference material
pharmaceutical secondary standard

Livello qualitativo

agenzia

traceable to Ph. Eur. P0950000
traceable to USP 1526200

Famiglia di API

phenoxyethanol

CdA

current certificate can be downloaded

tecniche

HPLC: suitable
gas chromatography (GC): suitable

P. eboll.

244-246 °C

Punto di fusione

11-13 °C

Densità

1.107 g/mL at 20 °C (lit.)

applicazioni

pharmaceutical (small molecule)

Formato

neat

Temperatura di conservazione

2-30°C

Stringa SMILE

OCCOc1ccccc1

InChI

1S/C8H10O2/c9-6-7-10-8-4-2-1-3-5-8/h1-5,9H,6-7H2
QCDWFXQBSFUVSP-UHFFFAOYSA-N

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Descrizione generale

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

2-Phenoxyethanol is a commonly used large spectrum-antimicrobial preservative used in cosmetic products and topical pharmaceutical preparations in the concentration range of 0.5–1.0%. It acts by inhibiting the coupling between the electron transport and phosphorylation reactions in mitochondria and disrupting ATP synthesis. It also prevents the activity of malate dehydrogenase and increases the permeability of cell membranes to potassium ions.

Applicazioni

The pharmaceutical secondary standard can also be used as follows:
  • To determine phenoxyethanol and its major metabolite, phenoxyacetic acid by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in rat plasma, urine, and 7 different tissue samples
  • Development of a reverse phase ultra-high-performance liquid chromatographic (RP-UHPLC) method to quantify 2-phenoxyethanol from commercially available human vaccines
  • Screening of cosmetic products (CPs) for 17 widely used preservatives by high-performance liquid chromatography-photodiode-array-electrospray ionization-mass spectrometry (HPLC-PDA-ESI/MS)
  • Thin layer chromatography (TLC)-densitometric determination of hydrocortisone acetate and 2-phenoxyethanol in cream samples
  • Analysis of eight volatile and semi-volatile ingredients in a topical formulation by gas chromatography (GC) coupled with a programmed temperature vaporizing (PTV) inlet and a flame ionization detector

Risultati analitici

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Nota a piè di pagina

To see an example of a Certificate of Analysis for this material enter LRAC2814 in the slot below. This is an example certificate only and may not be the lot that you receive.

Prodotti consigliati

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Esclusione di responsabilità

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

Prodotti correlati

N° Catalogo
Descrizione
Determinazione del prezzo

Pittogrammi

CorrosionExclamation mark

Avvertenze

Danger

Indicazioni di pericolo

Classi di pericolo

Acute Tox. 4 Oral - Eye Dam. 1 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

258.8 °F - closed cup

Punto d’infiammabilità (°C)

126 °C - closed cup


Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 7

1 of 7

Metiliparaben Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1012

Metiliparaben

Dehydroacetic acid Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1582

Dehydroacetic acid

Octisalate Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1081

Octisalate

Propilparabene Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1010

Propilparabene

Homosalate Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1085

Homosalate

Octocrylene Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1083

Octocrylene

Shao-Ping Weng et al.
Reproductive toxicology (Elmsford, N.Y.), 29(4), 452-457 (2010-04-13)
Ethylene glycol monomethyl ether (EGME) is known to alter the reproductive function of exposed animals and their offspring; however, its influence on cumulus-oocyte complexes (COCs) remains unclear. This study assessed the toxicity of EGME on oocytes and COCs by analyzing
Jessica Stahl et al.
International wound journal, 7(1), 62-69 (2010-04-23)
A combination of 0.1% octenidine dihydrochloride and 2% 2-phenoxyethanol (octenisept) is a commonly used disinfectant in human medicine. As porcine skin represents an adequate model for human skin, the effect of octenidine dihydrochloride and phenoxyethanol on wound healing is studied
Santosh K Tripathi et al.
Organic & biomolecular chemistry, 9(2), 581-587 (2010-11-05)
Syntheses of several diorganodiselenides and, in particular, a seven-membered cyclic seleninate ester derived from 2-phenoxyethanol are described. The seleninate ester was obtained from allyl (2-(2-hydroxyethoxy)phenyl) selenide through a series of oxidation and [2,3] sigmatropic rearrangement steps. The ester exhibits good
M Rosa Pena Ferreira et al.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 16(4), 444-449 (2010-10-07)
Age has a huge influence on skin roughness; with increasing age, the number of collagen and elastine fibers is reduced and elasticity decreases significantly. Pharmaceutical and cosmetics, environmental factors and lifestyle have an important effect on skin. In this study
Tirumurugaan Krishnaswamy Gopalan et al.
PloS one, 9(6), e100018-e100018 (2014-06-24)
From an immunologist perspective, sharks are an important group of jawed cartilaginous fishes and survey of the public database revealed a great gap in availability of large-scale sequence data for the group of Chondrichthyans the elasmobranchs. In an attempt to

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.