8.51095

PyOxim

≥99.0% (HPLC), for peptide synthesis, Novabiochem^®

• Sinonimo/i: PyOxim, 1-Cyano-2-ethoxy-2-oxoethylideneaminooxy-tris-pyrrolidino-phosphonium hexafluorophosphate
• Formula empirica (notazione di Hill): C₁₇H₂₉F₆N₅O₃P₂
• Numero CAS: 153433-21-7
• Peso molecolare: 527.38
• Numero MDL: MFCD18643381
• Codice UNSPSC: 12352126
• NACRES: NA.22

Proprietà

• Nome del prodotto: PyOxim, Novabiochem^®
• Livello qualitativo: 300
• Nome Commerciale: Novabiochem^®
• Saggio: ≥99.0% (HPLC)
• Stato: powder
• Impiego in reazioni chimiche: reaction type: Coupling Reactions
• Produttore/marchio commerciale: Novabiochem^®
• applicazioni: peptide synthesis
• Temperatura di conservazione: 15-25°C
• InChI: 1S/C17H29N5O3P.F6P/c1-2-24-17(23)16(15-18)19-25-26(20-9-3-4-10-20,21-11-5-6-12-21)22-13-7-8-14-22;1-7(2,3,4,5)6/h2-14H2,1H3;/q+1;-1/b19-16+;; RDWDVLFMPFUBDV-PXMDEAMVSA-N

Descrizione

Descrizione generale

PyOxim ^[1] is a novel reagent which mediates coupling reactions with efficiencies superior to HATU and PyBOP and comparable to COMU. It is has excellent solubility in DMF and is stable in solution under an inert atmosphere for two days. Unlike HATU and HBTU, it cannot cause chain terminating side reactions and is, therefore, ideal for the synthesis of cyclic peptides. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents.


Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] R. Subiros-Funosas, et al. (2010) Org. Biomol. Chem., 8, 3665.

Caratteristiche e vantaggi

• Mediates coupling with superior efficiency to PyBOP, TBTU, and HCTU
• Mediates coupling with low racemization or epimerization
• Ideal for fragment condensation and synthesis of cyclic peptides as the reagent cannot cause guanidinylation
• Excellent solubility in DMF and NMP

Risultati analitici

Colour (visual): white to off white
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 %
Solubility (1 mmole in 2 ml DMF): clearly soluble

Note legali

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable