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Merck
Tutte le immagini(1)

Documenti fondamentali

20-107

Sigma-Aldrich

Peroxynitrite

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About This Item

Codice UNSPSC:
41116012
eCl@ss:
32160405
NACRES:
NA.41

Stato

liquid

Livello qualitativo

Produttore/marchio commerciale

Upstate®

tecniche

western blot: suitable

Condizioni di spedizione

dry ice

Descrizione generale

Peroxynitrite (ONOO−) is a powerful oxidant formed by the collision of nitric oxide and superoxide.

Applicazioni

Peroxynitrite has been used to induce pericyte contraction in mouse brains. It has also been used for the preparation of positive control nitrated protein standards in immunohistochemical studies.

Azioni biochim/fisiol

Peroxynitrite (ONOO−) exhibits bactericidal activity. It promotes cell death and contributes to the signal-transduction process, mitochondrial function, and apoptotic pathway. The formation of peroxynitrite has been associated with the development of various diseases including vascular diseases, ischemia-reperfusion injury, circulatory shock, inflammation, pain, and neurodegeneration.

Qualità

Routinely evaluated by treating non-stimulated A431 cells.

Stato fisico

0.3M NaOH

Note legali

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Pittogrammi

Corrosion

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2

Codice della classe di stoccaggio

8B - Non-combustible corrosive hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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I clienti hanno visto anche

Csaba Szabó et al.
Nature reviews. Drug discovery, 6(8), 662-680 (2007-08-02)
Peroxynitrite--the product of the diffusion-controlled reaction of nitric oxide with superoxide radical--is a short-lived oxidant species that is a potent inducer of cell death. Conditions in which the reaction products of peroxynitrite have been detected and in which pharmacological inhibition
High-throughput, multiplexed analysis of 3-nitrotyrosine in individual proteins.
Hongjun Jin,Richard C Zangar
Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (editor-in-chief) ... [Et al.] null
Pathological implications of nitric oxide, superoxide and peroxynitrite formation.
Beckman, J S and Crow, J P
Biochemical Society Transactions, 21, 330-334 (1993)
Oxidative chemistry of peroxynitrite.
Beckman, J S, et al.
Test, 233, 229-240 (1994)
James Murray et al.
The Journal of biological chemistry, 278(39), 37223-37230 (2003-07-15)
There is growing evidence that oxidative phosphorylation (OXPHOS) generates reactive oxygen and nitrogen species within mitochondria as unwanted byproducts that can damage OXPHOS enzymes with subsequent enhancement of free radical production. The accumulation of this oxidative damage to mitochondria in

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