860657P
Avanti
sphingosine-d7
Avanti Research™ - A Croda Brand 860657P, powder
Sinonimo/i:
D-erythro-sphingosine-d7
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About This Item
Formula empirica (notazione di Hill):
C18H30D7NO2
Numero CAS:
Peso molecolare:
306.54
Numero MDL:
Codice UNSPSC:
12352211
NACRES:
NA.25
Prodotti consigliati
Stato
powder
Confezionamento
pkg of 1 × 1 mg (860657P-1mg)
pkg of 1 × 5 mg (860657P-5mg)
Produttore/marchio commerciale
Avanti Research™ - A Croda Brand 860657P
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Stringa SMILE
OC[C@@](N)([H])[C@@](O)([H])/C=C/CCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]
InChI
WWUZIQQURGPMPG-AVMMVCTPSA-N
Descrizione generale
Sphingosine-d7 is a deuterated derivative of sphingosine. Sphingosine is an important bioactive sphingolipid metabolite. It is a 18-carbon amino alcohol derived from sphingomyelin. Sphingosine contains an unsaturated hydrocarbon chain.
Applicazioni
Sphingosine-d7 has been used as an internal standard in liquid chromatography–tandem mass spectrometry for quantitative analysis of sphingolipids in biological samples.
Azioni biochim/fisiol
Sphingosine negatively regulates cell proliferation and induces apoptosis. It has an ability to regulate the activities of phospholipases, protein kinases, ion channels, cannabinoid receptor type 1 (CB-1) receptors and steroidogenic factor 1 (SF-1) receptors. Sphingosine acts as a precursor for ceramide synthesis.
Confezionamento
5 mL Amber Glass Screw Cap Vial (860657P-1mg)
5 mL Amber Glass Screw Cap Vial (860657P-5mg)
Note legali
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Comunemente ordinati con questo prodotto
N° Catalogo
Descrizione
Determinazione del prezzo
Codice della classe di stoccaggio
11 - Combustible Solids
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Henning Carstens et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 53(6), 1015-1028 (2019-12-20)
Pulmonary infections with Pseudomonas aeruginosa (P. aeruginosa) or Staphylococcus aureus (S. aureus) are of utmost clinical relevance in patients with cystic fibrosis, chronic obstructive pulmonary disease, after trauma and burn, upon ventilation or in immuno-compromised patients. Many P. aeruginosa and
Stephanie Schwalm et al.
The American journal of pathology, 187(11), 2413-2429 (2017-08-16)
Kidney fibrosis is a hallmark of chronic kidney disease and leads to extracellular matrix accumulation, organ scarring, and loss of kidney function. In this study, we investigated the role of sphingosine kinase-2 (SPHK2) on the progression of tubular fibrosis by
Iulia Zoicas et al.
Cells, 9(5) (2020-05-24)
Human and murine studies identified the lysosomal enzyme acid sphingomyelinase (ASM) as a target for antidepressant therapy and revealed its role in the pathophysiology of major depression. In this study, we generated a mouse model with overexpression of Asm (Asm-tgfb)
Irina Alecu et al.
Journal of lipid research, 58(1), 60-71 (2016-11-23)
The 1-deoxysphingolipids (1-deoxySLs) are atypical sphingolipids (SLs) that are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during SL synthesis. The 1-deoxySLs are toxic to neurons and pancreatic β-cells. Pathologically elevated 1-deoxySLs cause the inherited neuropathy, hereditary
Olivier Cuvillier
Biochimica et biophysica acta, 1585(2-3), 153-162 (2003-01-18)
The sphingolipid metabolites ceramide, sphingosine, and sphingosine 1-phosphate contribute to controlling cell proliferation and apoptosis. Ceramide and its catabolite sphingosine act as negative regulators of cell proliferation and promote apoptosis. Conversely, sphingosine 1-phosphate, formed by phosphorylation of sphingosine by a
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