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Key Documents

860659P

Avanti

sphingosine-1-phosphate-d7

Avanti Research - A Croda Brand 860659P, powder

Sinonimo/i:

D-erythro-sphingosine-d7-1-phosphate

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About This Item

Formula empirica (notazione di Hill):
C18H31D7NO5P
Numero CAS:
Peso molecolare:
386.51
Codice UNSPSC:
12352211
NACRES:
NA.25

Forma fisica

powder

Confezionamento

pkg of 1 × 1 mg (860659P-1mg)

Produttore/marchio commerciale

Avanti Research - A Croda Brand 860659P

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

[H][C@@]([C@]([NH3+])([H])COP([O-])(O)=O)(O)/C=C/CCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]

Descrizione generale

Sphingosine-1-phosphate (S1P) or D-erythro-sphingosine-d7-1-phosphate, is a deuterated sphingolipid. S1P, a zwitterionic sphingolipid, is an important cellular metabolite and signaling lipid in animal cells. It has also been found in insects, yeasts and plants. S1P is synthesized from the sphingosine kinase (Sph) 1 and SphK2 present in cytosol and nucleus, respectively.

Applicazioni

Sphingosine-1-phosphate (S1P)-d7 has been used as a standard in ultra-high performance liquid chromatography (UHPLC)-Q exactive for validation and quantitative analyses of S1P.

Azioni biochim/fisiol

Sphingosine-1-phosphate (S1P) plays a vital role in mammalian brain and cardiac development. It is essential for maturation of the systemic circulatory system and lymph vessels. Additionally, S1P is implicated in trafficking and effector functions of lymphocytes and other blood stem cells. It also provides protection against various forms of tissue injury. S1P also acts as a tumor promoting lipid. S1P has an ability to enhance erythrocyte glycolysis and oxygen delivery therefore, it can be used to treat tissue hypoxia.

Confezionamento

5 mL Amber Glass Screw Cap Vial (860659P-1mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Comunemente ordinati con questo prodotto

Codice della classe di stoccaggio

11 - Combustible Solids

Punto d’infiammabilità (°F)

No data available

Punto d’infiammabilità (°C)

No data available


Certificati d'analisi (COA)

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Avanti

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Avanti

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Sigma-Aldrich

S7049

D-Sphingosine

Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia
Sun K, et al.
Nature Communications, 7(7), 12086-12086 (2016)
Structural and functional insight of sphingosine 1-phosphate-mediated pathogenic metabolic reprogramming in sickle cell disease
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Scientific reports, 7(1), 15281-15281 (2017)
An update on sphingosine-1-phosphate and other sphingolipid mediators
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Nature Chemical Biology, 6(7), 489-489 (2010)
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 53(6), 1015-1028 (2019-12-20)
Pulmonary infections with Pseudomonas aeruginosa (P. aeruginosa) or Staphylococcus aureus (S. aureus) are of utmost clinical relevance in patients with cystic fibrosis, chronic obstructive pulmonary disease, after trauma and burn, upon ventilation or in immuno-compromised patients. Many P. aeruginosa and
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Human and murine studies identified the lysosomal enzyme acid sphingomyelinase (ASM) as a target for antidepressant therapy and revealed its role in the pathophysiology of major depression. In this study, we generated a mouse model with overexpression of Asm (Asm-tgfb)

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