D99234

Diethyl phosphite

98%

• Sinonimo/i: Diethoxyphosphine oxide, Diethyl acid phosphite, Diethyl hydrogen phosphite, Diethyl phosphonate, Hydrogen diethyl phosphite
• Formula condensata: (C₂H₅O)₂P(O)H
• Numero CAS: 762-04-9
• Peso molecolare: 138.10
• Beilstein: 605759
• Numero CE: 212-091-6
• Numero MDL: MFCD00044573
• Codice UNSPSC: 12352100
• ID PubChem: 24894335
• NACRES: NA.22

Proprietà

• Livello qualitativo: 200
• Saggio: 98%
• Stato: liquid
• Indice di rifrazione: n20/D 1.407 (lit.)
• P. ebollizione: 50-51 °C/2 mmHg (lit.)
• Densità: 1.072 g/mL at 25 °C (lit.)
• Stringa SMILE: [H]P(=O)(OCC)OCC
• InChI: 1S/C4H11O3P/c1-3-6-8(5)7-4-2/h8H,3-4H2,1-2H3; MJUJXFBTEFXVKU-UHFFFAOYSA-N

Descrizione

Descrizione generale

Diethyl phosphite is the organophosphorus compound used as a phosphorylating agent in organic synthesis.

Applicazioni

Applications of diethyl phosphite (DEP):

• It can undergo condensation with aldehydes or ketones and an amine to form α-aminophosphonates under solvent-free and catalyst-free conditions.
• Reduction of gem-dibromo derivatives using diethyl phosphite in the presence of triethylamine gives monobromocyclopropanes.
• Along with 4-dimethylaminopyridine, it can be used as a ligand for nickel-catalyzed cross-coupling of aryl and heteroaryl bromides, chlorides or sulfonates with arylzinc reagents.
• It can be used for the catalytic asymmetric hydrophosphonylation of enones in the presence of a dinuclear zinc complex to form γ-oxo-phosphonates.
• DEP can undergo Michael addition to α,β-unsaturated malonates to form β-phosphonomalonates in the presence of recyclable nano γ-ferric oxide-pyridine based catalyst.

Informazioni sulla sicurezza

• Pittogrammi: GHS05,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H317,H318
• Consigli di prudenza: P261 - P272 - P280 - P302 + P352 - P305 + P351 + P338 - P333 + P313
• Classi di pericolo: Eye Dam. 1 - Skin Sens. 1B
• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): 179.6 °F - closed cup
• Punto d’infiammabilità (°C): 82 °C - closed cup
• Dispositivi di protezione individuale: Eyeshields, Gloves, type ABEK (EN14387) respirator filter