D178454

Dimethyl phosphite

98%

• Sinonimo/i: Dimethoxyphosphine oxide, Dimethyl hydrogen phosphite, Dimethyl hydrogen phosphonate, Dimethyl phosphonate, Hydrogen dimethyl phosphite
• Formula condensata: (CH₃O)₂P(O)H
• Numero CAS: 868-85-9
• Peso molecolare: 110.05
• Beilstein: 1697490
• Numero CE: 212-783-8
• Numero MDL: MFCD00044633
• Codice UNSPSC: 12352100
• ID PubChem: 24893543
• NACRES: NA.22

Proprietà

• Livello qualitativo: 200
• Saggio: 98%
• Stato: liquid
• Impurezze: ≤0.5% trimethyl phosphate; ≤1% methyl alcohol
• Indice di rifrazione: n20/D 1.402 (lit.)
• P. ebollizione: 170-171 °C (lit.)
• Densità: 1.2 g/mL at 25 °C (lit.)
• Stringa SMILE: [H]P(=O)(OC)OC
• InChI: 1S/C2H7O3P/c1-4-6(3)5-2/h6H,1-2H3; HZCDANOFLILNSA-UHFFFAOYSA-N

Descrizione

Applicazioni

Dimethyl phosphite is used in the synthesis of α-aminophosphonates, which are medicinally important phosphorus analogs of amino acids, by treating with an amine and an aldehyde or a ketone. It can also be employed in asymmetric hydrophosphonylation of aldehydes to synthesize optically active α-hydroxy phosphonates.

Dimethyl phosphite may be used as an effective alternative to organic tin hydrides as radical reducing agents for organic halides, thionoesters, and isocyanides to form the corresponding hydrocarbons. Radical translocation/cyclization reactions of terminal alkynes to form cyclic phosphonates can also be effectively carried using dimethyl phosphite as a reagent under tin-free condition.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H317,H341,H351,H412
• Consigli di prudenza: P202 - P261 - P273 - P280 - P302 + P352 - P308 + P313
• Classi di pericolo: Aquatic Chronic 3 - Carc. 2 - Muta. 2 - Skin Sens. 1
• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): 158.0 °F - closed cup
• Punto d’infiammabilità (°C): 70 °C - closed cup
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter