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677175

Sigma-Aldrich

Pyruvic-1-13C acid (free acid)

≥99 atom % 13C, ≥99% (CP)

Sinonimo/i:

α-Ketopropionic acid-1-13C, 2-Oxopropionic acid-1-13C, 13C Labeled pyruvic acid, Pyruvic acid-1-13C

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About This Item

Formula condensata:
CH3CO13CO2H
Numero CAS:
99124-30-8
Peso molecolare:
89.05
Numero MDL:
MFCD10566986
Codice UNSPSC:
12352106
ID PubChem:
329760673
NACRES:
NA.12

Purezza isotopica

≥99 atom % 13C

Livello qualitativo

200

Saggio

≥99% (CP)

P. ebollizione

165 °C

Punto di fusione

11-12 °C

Densità

1.281 g/mL at 25 °C

Spostamento di massa

M+1

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

CC(=O)[13C](O)=O

InChI

1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/i3+1
LCTONWCANYUPML-LBPDFUHNSA-N

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Descrizione generale

Pyruvic-1-13C is isotopic labeled precursor of pyruvic acid.

Applicazioni

Hyperpolarized 13C-labeled pyruvate and its metabolite lactate has been used to image real time metabolic flux in solid tumors and assess tumor response to chemotherapy, radiation, and agents targeting mTOR.

Confezionamento

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Pittogrammi

Corrosion
GHS05

Avvertenze

Danger

Indicazioni di pericolo

H314

Classi di pericolo

Eye Dam. 1 - Skin Corr. 1C

Codice della classe di stoccaggio

8A - Combustible corrosive hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

179.6 °F - closed cup

Punto d’infiammabilità (°C)

82 °C - closed cup

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Certificati d'analisi (COA)

Lot/Batch Number
MBBD2813
MBBD1214
MBBC8002
MBBC4409
MBBC6541

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Ilwoo Park et al.
Journal of magnetic resonance imaging : JMRI, 33(6), 1284-1290 (2011-05-19)
To demonstrate the feasibility of using DNP hyperpolarized [1-(13)C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model. Twenty athymic rats with intracranial implantation of human glioblastoma cells were divided into two groups: one
Mette Hauge Lauritzen et al.
NMR in biomedicine, 26(11), 1496-1500 (2013-06-25)
A change in myocardial metabolism is a known effect of several diseases. MRS with hyperpolarized (13)C-labelled pyruvate is a technique capable of detecting changes in myocardial pyruvate metabolism, and has proven to be useful for the evaluation of myocardial ischaemia
Prasanta Dutta et al.
Cancer research, 73(14), 4190-4195 (2013-06-01)
Hyperpolarized (13)C magnetic resonance spectroscopy provides a unique opportunity to detect real-time metabolic fluxes as a means to measure metabolic treatment responses in vivo. Here, we show that pharmacologic inhibition of lactate dehydrogenase-A suppressed the conversion of hyperpolarized (13)C-pyruvate to
Albert P Chen et al.
Magnetic resonance in medicine, 73(6), 2087-2093 (2014-07-22)
Hyperpolarized [1-(13) C]lactate in solution may be a clinically relevant and safe substrate for real time MR investigations of key metabolic pathways. The potential of using hyperpolarized [1-(13) C]lactate for magnetic resonance studies of cardiac metabolism in vivo was explored.

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