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W6578

Sigma-Aldrich

Pyruvic-1-13C acid (free acid)

API for Clinical Studies, ≥99 atom % 13C

Sinonimo/i:

α-Ketopropionic acid-1-13C, 2-Oxopropionic acid-1-13C, 13C Labeled pyruvic acid, Pyruvic acid-1-13C

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About This Item

Formula condensata:
CH3CO13CO2H
Numero CAS:
99124-30-8
Peso molecolare:
89.05
Numero MDL:
MFCD10566986
Codice UNSPSC:
12352106
ID PubChem:
329830758
NACRES:
NA.12

Grado

cGMP

Livello qualitativo

400

Purezza isotopica

≥99 atom % 13C

Saggio

≥95% (CP)

P. eboll.

165 °C

Punto di fusione

11-12 °C

Spostamento di massa

M+1

Condizioni di spedizione

dry ice

Temperatura di conservazione

-10 to -25°C

Stringa SMILE

CC(=O)[13C](O)=O

InChI

1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)/i3+1
LCTONWCANYUPML-LBPDFUHNSA-N

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Descrizione generale

Pyruvic-1-13C is isotopic labeled precursor of pyruvic acid.

Applicazioni

Hyperpolarized 13C-labeled pyruvate and its metabolite lactate has been used to image real time metabolic flux in solid tumors and assess tumor response to chemotherapy, radiation, and agents targeting mTOR.

Confezionamento

Typically, this product is available to ship immediately from stock. Contact Stable Isotopes Customer Service to discuss quantity and packaging needs.

Pittogrammi

Corrosion
GHS05

Avvertenze

Danger

Indicazioni di pericolo

H314

Classi di pericolo

Eye Dam. 1 - Skin Corr. 1C

Codice della classe di stoccaggio

8A - Combustible corrosive hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

179.6 °F - closed cup

Punto d’infiammabilità (°C)

82 °C - closed cup

Certificati d'analisi (COA)

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Sodium pyruvate-13C3 99 atom % 13C

Sigma-Aldrich

490717

Sodium pyruvate-13C3

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Sigma-Aldrich

8.20170

Pyruvic acid

Acido piruvico 98%

Sigma-Aldrich

107360

Acido piruvico

Ilwoo Park et al.
Journal of magnetic resonance imaging : JMRI, 33(6), 1284-1290 (2011-05-19)
To demonstrate the feasibility of using DNP hyperpolarized [1-(13)C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model. Twenty athymic rats with intracranial implantation of human glioblastoma cells were divided into two groups: one
Mette Hauge Lauritzen et al.
NMR in biomedicine, 26(11), 1496-1500 (2013-06-25)
A change in myocardial metabolism is a known effect of several diseases. MRS with hyperpolarized (13)C-labelled pyruvate is a technique capable of detecting changes in myocardial pyruvate metabolism, and has proven to be useful for the evaluation of myocardial ischaemia
Prasanta Dutta et al.
Cancer research, 73(14), 4190-4195 (2013-06-01)
Hyperpolarized (13)C magnetic resonance spectroscopy provides a unique opportunity to detect real-time metabolic fluxes as a means to measure metabolic treatment responses in vivo. Here, we show that pharmacologic inhibition of lactate dehydrogenase-A suppressed the conversion of hyperpolarized (13)C-pyruvate to
Albert P Chen et al.
Magnetic resonance in medicine, 73(6), 2087-2093 (2014-07-22)
Hyperpolarized [1-(13) C]lactate in solution may be a clinically relevant and safe substrate for real time MR investigations of key metabolic pathways. The potential of using hyperpolarized [1-(13) C]lactate for magnetic resonance studies of cardiac metabolism in vivo was explored.

Articoli

MRI/MRS: Use of Isotopes in Hyperpolarization

Sigma-Aldrich.com presents an article concerning MRI/MRS and the use of isotopes in hyperpolarization.

Dynamic Nuclear Polarization

Dynamic Nuclear Polarization (DNP) is a phenomenon by which high spin polarization, typically derived from a bath of free radical electrons, is transferred to a nuclear spin bath, enhancing the difference between the nuclear energy levels and thereby producing dramatically enhanced NMR signals for detection.

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

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